Wednesday, June 23, 2021

Insilico collaborates with Teva on AI system for target discovery

 


Insilico enters into a collaboration with Teva to apply novel generative artificial intelligence for the discovery of potential therapeutic targets

Tuesday, June 22, 2021 - Insilico Medicine is pleased to announce that it has entered into a collaboration with Teva Branded Pharmaceutical Products R&D, Inc. to utilize Insilico's generative machine learning technology and proprietary PandaOmics Drug Discovery Platform, which aims at identifying novel therapeutic targets implicated in a variety of diseases.

"Teva is a global leader in generics and specialty medicines, and we are happy to be contributing to its research and development efforts, especially in the field of novel target discovery," said Alex Zhavoronkov, PhD, CEO of Insilico Medicine.

PandaOmics is a comprehensive AI-powered platform for novel target discovery integrating over 60 different engines and approaches to target discovery. It provides biologically interpretable insights coupled with business intelligence with multiple experimentally validated case studies.

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About Insilico Medicine:

Since 2014 Insilico Medicine is focusing on generative models, reinforcement learning (RL), and other modern machine learning techniques for the generation of new molecular structures with the specified parameters, generation of synthetic biological data, target identification, and prediction of clinical trial outcomes. Recently, Insilico Medicine secured $37 million in series B funding. Since its inception, Insilico Medicine raised over $52 million, published over 100 peer-reviewed papers, applied for over 25 patents, and received multiple industry awards. Website http://insilico.com/.

Tuesday, June 22, 2021

Insilico Medicine Raises $255 Million in Series C Financing Led by Warburg Pincus



 NEW YORK and HONG KONGJune 22, 2021 /PRNewswire/ -- Insilico Medicine, a global leader in end-to-end artificial intelligence for target discovery, small molecule chemistry, and clinical development, announced that it has closed a $255 million Series C financing led by Warburg Pincus. The financing was also participated by current investors including Qiming Venture Partners, Pavilion Capital, Eight Roads Ventures, Lilly Asia Ventures, Sinovation Ventures, BOLD Capital Partners, Formic Ventures, Baidu Ventures, and new investors including CPE, OrbiMed, Mirae Asset Capital, B Capital Group, Deerfield Management, Maison Capital, Lake Bleu Capital, President International Development Corporation, Sequoia Capital China and Sage Partners.

As a pioneer and leader in the industry, Insilico Medicine has built a strong drug discovery and drug development team, a broad distributed discovery partner network, and initiated multiple internal therapeutic programs.  The Company demonstrated the first case of AI identifying a novel target for a major pulmonary disease, generating novel molecules for that novel target, and completing the preclinical experiments required to nominate a preclinical candidate in under 18 months. Insilico Medicine also developed the AI-powered drug discovery platform consisting of PandaOmics™ AI-powered novel target discovery engine, Chemistry42™ deep generative reinforcement learning system allowing for de-novo design of novel molecules with the desired properties that do not exist in the known chemical space, and InClinico™, which predicts clinical trial outcomes.

Proceeds from the financing will be used to progress Insilico Medicine's current therapeutic programs into human clinical trials, initiate multiple new programs for novel and difficult targets, and further develop its AI and drug discovery capabilities.

Alex Zhavoronkov, PhD, founder and CEO of Insilico Medicine said, "The artificial intelligence technologies we invented are now demonstrating impressive results in both biology and chemistry delivering valuable and absolutely novel therapeutic assets with high probability of clinical success.  We are pleased and proud to have gained the recognition and investment from some of the world's most reputable investors with strong expertise in the biopharmaceutical industry. With their support, we will continue to innovate and bring revolutionary solutions to the pharmaceutical industry.

"Min Fang, Managing Director at Warburg Pincus, will join Insilico Medicine's Board of Directors.

Fred Hassan, former Chairman and CEO of Schering Plough Corporation, commented on behalf of Warburg Pincus, "Artificial Intelligence and Machine Learning is a powerful tool to revolutionize the drug discovery process and bring life-changing therapies to patients faster than ever before. We are pleased to partner with Insilico, which has demonstrated strong value proof of its AI technologies both through partnerships with leading pharmaceutical and biotech companies and the development of exciting internal pipeline.  Insilico fits strongly with our strategy of investing in the best-in-class innovators in the healthcare and we will continue to support the company's ambitious vision of transforming drug discovery through harnessing AI and Machine Learning."

Since the previous round of financing, Insilico Medicine is making its technologies available for licensing for the leading pharmaceutical and biotechnology companies looking to gain a head start in AI and accelerate their drug discovery programs. It has collaborated with first-in-class biopharmaceutical companies, including Pfizer, Astellas, Johnson & Johnson, Taisho, and many others, with multiple partners reaching major milestones. Insilico Medicine also exclusively partnered with the main innovative sustainable agriculture company, Syngenta, on the discovery of novel molecules for sustainable regenerative farming.  Since the launch of Chemistry42 in September 2020, 7 out of the top 30 pharmaceutical companies deployed its software, including Merck KGaA and UCB.  Insilico Medicine also built a drug discovery team and platform in China and started multiple therapeutic programs targeting novel, difficult, and previously undruggable targets.

About Insilico Medicine

Insilico Medicine develops artificial intelligence systems that utilize deep generative models, reinforcement learning (RL), transformers, and other modern machine learning techniques for the generation of new molecular structures with specific properties. Insilico Medicine also develops software for the generation of synthetic biological data, target identification, and the prediction of clinical trials outcomes. The company integrates two business models; providing AI-powered drug discovery services and software through its Pharma.AI platform (www.insilico.com/platform/) and developing its own pipeline of preclinical programs. It has demonstrated the ability to identify the novel target for a major disease, generate and validate novel molecules with the desired properties for that target and nominate a preclinical candidate in under 18 months. Since its inception in 2014, Insilico Medicine has raised over $310 million from expert pharmaceutical, and technology investors, and received multiple industry awards. Insilico Medicine has also published over 130 peer-reviewed papers and has applied for over 30 patents. For more information, please visit www.insilico.com.

About Warburg Pincus

Warburg Pincus LLC is a leading global private equity firm focused on growth investing. The firm has more than $60 billion in private equity assets under management. The firm's active portfolio of more than 200 companies is highly diversified by stage, sector, and geography. Warburg Pincus is an experienced partner to management teams seeking to build durable companies with sustainable value. Founded in 1966, Warburg Pincus has raised 19 private equity funds, which have invested more than $90 billion in over 930 companies in more than 40 countries.

Since entering China in 1994, Warburg Pincus has invested nearly $14 billion in nearly 140 companies in the region. Warburg Pincus is one of the most active investors in the China healthcare industry, having invested more than $1.85 billion in the sector. Select investment cases include Abbisko Therapeutics, Haihe Biopharma, Lepu Medical, Wuxi AppTec, China Biologics, Hygeia and Jinxin Fertility, etc. For more information please visit www.warburgpincus.com.

CONTACT: Polly Firs, polly.firs@insilicomedicine.com

SOURCE Insilico Medicine Hong Kong Limited

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Wednesday, June 9, 2021

The Indiana Biosciences Research Institute deploys Insilico PandaOmics AI for target discovery


 Insilico Medicine collaborates with the Indiana Biosciences Research Institute to apply novel artificial intelligence-powered approaches to multi-omics data analysis and discovery of potential therapeutic targets

June 9, 2021 - Insilico Medicine, a global leader in deep learning for drug discovery and development, is pleased to announce that it has entered into a research collaboration with the Indiana Biosciences Research Institute (IBRI). The IBRI will use Insilico's generative machine learning technology and proprietary PandaOmics Drug Discovery Platform to identify novel therapeutic targets implicated in a variety of diseases, OMICS data analysis, and systems biology research.

"PandaOmics is a comprehensive AI-powered platform that will help improve our drug discovery processes and accelerate translational research," said Dr. Daniel Robertson, vice president of digital technology at the IBRI. "This platform will enable us to quickly access, analyze, visualize, and interpret externally-available data effectively to drive our research efforts."

Target discovery is the most risky yet rewarding area in healthcare. It is easy to pick the target for a specific disease, but the wrong choice will result in a Phase II clinical trial failure many years and spending of hundreds of millions of dollars later. Target discovery is usually performed in academic, research and clinical institutions, where the world's most competent researchers formulate disease hypotheses and perform the exploratory experiments. AI systems that incorporate and accelerate the many target discovery philosophies that worked in the past in addition to the novel approaches are likely to significantly increase the chances of successful target discovery.

"Since 2014 we have been developing AI, advanced bioinformatics, and business intelligence tools to identify novel targets for a variety of diseases. Many of these tools and target discovery philosophies are now available in PandaOmics, and we are very happy that the leading research institutions specializing in novel drug discovery are using PandaOmics to augment their discovery capabilities," said Alex Zhavoronkov, PhD, CEO of Insilico Medicine.

PandaOmics integrates more than 60 different engines and approaches to target discovery. It provides biologically interpretable insights coupled with business intelligence with multiple experimentally validated case studies. PandaOmics aims to be the go-to platform for all biologists and clinicians, working with various OMICS datasets.

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About Insilico Medicine:

Since 2014 Insilico Medicine has been focusing on generative models, reinforcement learning (RL), and other modern machine learning techniques for the generation of new molecular structures with the specified parameters, generation of synthetic biological data, target identification, and prediction of clinical trials outcomes. Recently, Insilico Medicine secured $37 million in series B funding. Since its inception, Insilico Medicine raised over $52 million, published over 130 peer-reviewed papers, applied for over 25 patents, and received multiple industry awards. Website http://insilico.com/

About Indiana Biosciences Research Institute:

The Indiana Biosciences Research Institute (IBRI) is a nonprofit discovery science and applied research institute currently targeting diabetes, metabolic disease, poor nutrition and related health data science. Inspired by Indiana's leading life sciences companies, research universities and philanthropic community, the IBRI is building a world-class organization of researchers, innovators and entrepreneurs to catalyze scientific discovery and its applications, resulting in improved health outcomes for Indiana patients and beyond. For more information about the IBRI, visit https://www.indianabiosciences.org/.

For further information, images or interviews, please contact: polly.firs@insilico.com