Saturday, September 13, 2014

Big Data Science in Medicine 2014: Accelerating Longevity Research


The Oxford University Scientific Society Welcomes Deep Knowledge Ventures and the Biogerontology Research Foundation (BGRF) to jointly host Big Data Science in Medicine 2014. This event brings together leading lights from artificial intelligence, biomedical science and regenerative medicine for an evening of talks and discussion in Oxford with the ambition of accelerating research on ageing.

Speakers: Aubrey de Grey, Alex Zhavoronkov, Joao Pedro de Magalhaes,Avi Roy, Dmitry Kaminskiy, Riva-Melissa Tez and Geoffrey Furlonger

With support from: Oxford Transhumanism and Emerging Technologies,SynoxHeales: Healthy life extension societyInternational Longevity AllianceFuture of Humanity Institute (Oxford University)British Science Association Oxfordshire BranchAging Analytics AgencySENS FoundationInSilico MedicineBritish Institute of Posthuman StudiesThe Human Memome Project, and London Futurists


The event is free to attend, but places are limited. Register for free here:http://www.bigdatamed.org/

Tuesday, September 9, 2014

Angelico Ventures



Just want to share important information and help my frend - David Oreshin :

 

Dear friends! I am currently looking for an investor for Angelico Ventures www.angelicoventures.com as we are fully invested and would like to continue to follow our path to achieving our mission in making the world free of ageing and disease. If you share our mission and would like to help us but you can't invest we are grateful for any help with sales, marketing, PR, GR, HR, IR, media, programming, design, fundraising etc. We welcome new partners to join Angelico Ventures team for sweat equity and profit sharing.
As an alternative I am looking for a full time job with a large or well funded organization, start up, high net worth individual in any field of business that will allow me to make good money through achieving the company goals and objectives so one day I can come back to Angelico Ventures business and make the world free of ageing and disease.
David Yury Oreshin is the founder of the first in Russia and CIS life sciences investment bank, VC, PE company Angelico Ventures, co founder of Alvansa Limited - pharmaceutical holding backed by Gazprombank and UFG Private Equity, founder of Angelico Pharmaceuticals. CEO of the Russian subsidiary of CureLab Oncology.
Angelico Ventures is a venture capital investment company focused on cancer, heart disease, neurodegenerative diseases, ageing and other therapeutic areas worldwide.
Angelico Management Consulting brings the world’s leading management consulting practice in life sciences to life sciences companies and investors.
Angelico Investment Banking is focused on the development of the global life sciences industry by bringing together only the best life sciences companies and investors worldwide. Major deals include Gazprombank and UFG Private Equity $200M investment in Alvansa Limited, pharmaceutical holding focused on pharmaceutical industry consolidation in Russia. NauchTekhStroy Plus (joint venture subsidiary of Pharmstandard, Russia's leading domestic pharmaceutical company) $58M investment and strategic alliance deal with Affitech, world’s leading monoclonal antibody company focused on development of new cancer therapeutics.
Angelico Pharmaceuticals is focused on development, registration, sales and marketing of nutriceuticals, pharmaceuticals and biopharmaceuticals that are safe and effective against major age related diseases such as cancer, heart disease, neurodegenerative diseases and other diseases. The mission of Angelico Pharmaceuticals is to generate revenue to finance radical life extension by saving lives of people and improving the quality of life. All Angelico Pharmaceuticals products are focused on human life extension by preventing, treating and providing support to the patients during the treatment of major age related diseases.
Angelico Radical Life Extension is focused on ending ageing by fixing genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intracellular communication. Angelico Radical Life Extension is currently in R&D stage and is going to laser beam focus on one product for radical human life extension that will ve also active against certain types of cancers by the end of 2014. Angelico Radical Life Extension is planning to start animal trials of our first product for radical human life extension in 2015. After obtaining promising data from animal trials Angelico Radical Life Extension will apply for IND in USA and approval to conduct clinical trials in Russia. We plan to position our first product for radical human life extension on the pharmaceutical market as a cancer drug active against certain types of cancers with a highly positive side effect of radical life extension. This approach allows Angelico Radical Life Extension to develop our first product for radical human life extension using traditional approach to pre-clinical and clinical trials, registration, sales and marketing of a biopharmaceutical drug what is going to simplify product development, registration, market entry and growth.
To contact me please e-mail: y.oreshin@angelicoventures.com

You may also see on facebook: https://www.facebook.com/y.oreshin/posts/10204551238402545 

Google Calico

AbbVie and Calico Announce a Novel Collaboration to Accelerate the Discovery, Development, and Commercialization of New Therapies

California Life Company
Calico to create a leading R&D facility in the San Francisco Bay Area focused on aging and age-related diseases, including neurodegeneration and cancer
AbbVie and Calico may co-invest up to $1.5 billion, utilizing Calico’s discovery and early development capabilities and AbbVie’s broad research, development, and commercial expertise to advance innovative new therapies
NORTH CHICAGO, Ill. and SOUTH SAN FRANCISCO, Calif., Sept. 3, 2014 –AbbVie (NYSE:ABBV) and Calico announced a novel R&D collaboration intended to help the two companies discover, develop and bring to market new therapies for patients with age-related diseases, including for neurodegeneration and cancer.
Calico is the Google-backed life sciences company led by Arthur D. Levinson, Ph.D. (former chairman and CEO of Genentech) and Hal V. Barron, M.D. (former Executive Vice President and Chief Medical Officer of Genentech). The agreement paves the way for Calico to establish a world-class research and development facility in the San Francisco Bay Area.
Under the agreement, the companies will combine their complementary strengths to accelerate the availability of new therapies for age-related diseases:
  • Calico will use its scientific expertise to establish a world-class research and development facility, with a focus on drug discovery and early drug development; and
  • AbbVie will provide scientific and clinical development support and its commercial expertise to bring new discoveries to market.
“This collaboration demonstrates our commitment to exploring new areas of medicine and innovative approaches to drug discovery and development that augments our already robust pipeline,” said Richard A. Gonzalez, Chairman of the Board and Chief Executive Officer, AbbVie. “We are pleased to be working with such outstanding scientists as Art Levinson, Hal Barron and their team. The potential to help improve patients’ lives with new therapies is enormous.”
“Our relationship with AbbVie is a pivotal event for Calico, whose mission is to develop life-enhancing therapies for people with age-related diseases. It will greatly accelerate our efforts to understand the science of aging, advance our clinical work, and help bring important therapies to patients everywhere,” said Art Levinson, CEO and founder of Calico.

Details of the Research Collaboration
  • AbbVie and Calico will each initially provide up to $250 million to fund the collaboration with the potential for both sides to contribute an additional $500 million
  • Calico will be responsible for research and early development during the first five years and continue to advance collaboration projects through Phase 2a for a ten-year period
  • AbbVie will support Calico in its early R&D efforts and, following completion of Phase 2a studies, activities
  • Both parties will share costs and profits equally
“We are thrilled to have the opportunity to work with the many outstanding scientists at AbbVie to ensure that the important science at Calico is advanced quickly to benefit patients,” said Hal Barron, M.D., President of Research and Development at Calico.
"We are extremely proud to have our research teams partnering with Calico as we aim to address treatments for diseases of aging,” said Michael Severino, M.D., Executive Vice President, Research and Development, and Chief Scientific Officer, AbbVie. "Our broad R&D experience and capabilities will complement Calico's biotechnology expertise and innovative scientific approaches. Together, we are confident that we will bring new therapeutic solutions to patients."
Calico expects to begin filling critical positions immediately, and plans to establish a substantial team of scientists and research staff in the San Francisco Bay Area.

About AbbVie
AbbVie is a global, research-based biopharmaceutical company formed in 2013 following separation from Abbott Laboratories. The company's mission is to use its expertise, dedicated people and unique approach to innovation to develop and market advanced therapies that address some of the world's most complex and serious diseases. AbbVie employs approximately 25,000 people worldwide and markets medicines in more than 170 countries. For further information on the company and its people, portfolio and commitments, please visit www.abbvie.com. Follow@abbvie on Twitter or view careers on our Facebook or LinkedIn page.

About Calico
Calico (California Life Sciences LLC) is a Google-founded research and development company whose mission is to harness advanced technologies to increase our understanding of the biology that controls lifespan. We will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Visit www.calicolabs.com.

InSilico Medicine salutes Calico and AbbVie partnership, paves way for Basel conference

The recently formed R&D partnership between Calico and AbbVie paves a pathway for aging research as the new industry, with more details at the MipTec 2014 conference in Switzerland


Aging research has long been regarded by the pharmaceutical industry as a subject of controversy associated with failed expectations, ineffective remedies, and blatantly false claims. However, the explosion of the research and clinical data, fueled by the drop in sequencing costs and technology convergence, has led to the emergence of projects with credible business models and approaches targeting both the age-related diseases as well as the aging-associated processes. Advances in aging biomarkers and in silico drug screening methods may soon enable the pharmaceutical industry to revisit their business models and reshape the regulatory frameworks.AbbVie and Google-backed Calico announced yesterday that they will co-invest up to $1.5 billion to create a leading R&D facility focused on aging and age-related diseases, including neurodegeneration and cancer. This center will be located in the San Francisco Bay Area, and the amalgamation of the two companies serves as a trailblazer for similar research teams dedicated to eradicating aging and age-related diseases.
InSilico Medicine, Inc. is thrilled about this new collaboration and its innovative potential. "InSilico Medicine, Inc. has developed several methods for geroprotector and geroprotector combination discovery and screening that are undergoing pre-clinical validation with multiple publications out, in review, and in the pipeline. We must thank Google for paving the way and setting the trend. After they got involved in this field, it gained a lot of credibility. In our opinion it is not a competitor, it is a bulldozer, which will pave the way for the many innovative companies like us." InSilico Medicine CEO, Alex Zhavoronkov, says. "We salute Calico and AbbVie for spearheading the revolution in aging drug discovery and setting the example for other pharmaceutical companies to follow. These are fantastic news for InSilico Medicine, Inc., Human Longevity, Inc., Retrotope, Pathway Pharmaceuticals and many other companies pursuing age-related diseases and aging itself."

With the MipTec 2014 conference in such close proximity to this notable collaboration, there is a great deal excitement for the experts, industries, and enthusiasts of aging therapies. The conference will host exceptional speakers, elaborate forums, and a variety of sponsors and exhibitors all dedicated to practical applications of aging. The conference serves as a bridge for scientists and the pharmaceutical and biotechnology industries to discover the potential for drug screening and discovery platforms for age-related disease. As more companies such as Calico and AbbVie continue to enter the field of aging research, forums like MipTec will increase in popularity and unite partners from a large variety of organizations on an international scale.

###

More information on MipTec 2014 can be found at http://www.agingpharma.org/.

About InSilico Medicine


InSilico Medicine was founded in early 2014 and has since developed the GeroScopeTM geroprotector scrreening platform and extended the use of exclusively licensed OncoFinder™ system into drug discovery and research. It is a company dedicated to finding novel solutions towards aging and age-related diseases using advances in genomics and big data analysis. Through internal expertise and extensive collaborations with brilliant scientists, institutions, and highly credible pharmaceutical companies, InSilico Medicine seeks to revolutionize personalized science and drug discovery. More can be read about InSilico Medicine, Inc. at http://www.insilicomedicine.com.

Wednesday, July 9, 2014

V-A-C-A-T-I-O-N

At last all examinations are already passed. I am very happy that i've got an oncology internship.
 There are many deals which were to be made: to improve skills in English, study of oncology, statistics, study to investment, getting drive licence and to resolve an issue with living in Moscow (since constantly to move from place to place it is a huge waste of time, money and forces). But i have to forget about this deals. As someone spoke in the "Godfather" movie, "you should spend time for family" therefore I think that it is necessary to forget about blogs to september. I wish    this summer will be unforgettable and interesting for you my Dear Reader!
 

Thursday, June 5, 2014

The Former Head of the Human Genome Project Joins InSilico Medicine, Inc. in the War on Aging as the Chair of the SAB

Charles Cantor, PhD, professor emeritus at Boston University and former principal scientist of the Human Genome Project joined the Science Advisory Board of InSilico Medicine, Inc.

BALTIMORE, Md., June 4, 2014 (GLOBE NEWSWIRE) -- via PRWEB - InSilico Medicine, Inc. announced today that Charles Cantor, Ph.D. will chair its Scientific Advisory Board.
Dr. Cantor, one of the leaders of the Human Genome Project, has published more than 400 peer-reviewed articles, authored and co-authored more than 50 U.S. and international patents. He is also an author of the first genomics textbook, "Genomics: The Science and Technology of the Human Genome Project" and the three-volume textbook "Biophysical Chemistry".

"Professor Cantor's discoveries and leadership are already helping save lives and improve human health span. What is less known is his interest in areas related to aging including the complex and multi-year research projects in isotopically-fortified organic compounds and advanced diagnostics using the cell-free nucleic acids. He is the role model for the many research scientists aspiring to utilize resources available in the private sector, accelerate scientific research without the many formal constraints and budgetary limitations of academia and turn their discoveries into practical projects. We are honored to have Charles join our advisory board", said Alex Zhavoronkov, PhD, CEO of InSilico Medicine, Inc. 

Dr. Cantor is the co-founder of Sequenom, Inc, a company engaged in non-invasive prenatal diagnostics and co-founder of Retrotope, a company developing isotopically-fortified organic compounds to bolster stress resistance and combat age-related diseases and acts as a consultant for several companies within the biotechnology industry. He is professor emeritus at the Boston University, distinguished adjunct professor at the University of California Irvine and adjunct professor at the Moscow Institute of Physics and Technology and at Scripps Research Institute. Dr. Cantor was previously the chair and professor of the department of biomedical engineering and biophysics, and director of the Center for Advanced Biotechnology at Boston University, and his research laboratory remains active.

"Aging is one of the most pressing problems facing the economies of the developed countries and there is an urgent need for new ways to increase productive longevity and screening the known drugs for their geroprotective properties and personalizing anti-cancer and aging-suppressive regiments using genetic and epigenetic analysis is one of the low hanging fruits in applied aging research. I am pleased to join the SAB of this international team dedicated to develop working solutions for both aging and age-related diseases", said Charles Cantor, PhD, chair of the Science Advisory Board of InSilico Medicine, Inc.
Dr. Cantor was the chairman of Genetics and Development at Columbia University College of Physicians & Surgeons, and Professor of Molecular Biology, University of California, Berkeley.
He earned his bachelor's degree in chemistry at Columbia College, and his doctorate at the University of California Berkeley.

About InSilico Medicine, Inc.

Insilico Medicine, Inc. is a Baltimore-based bioinformatics and drug discovery company specializing in cancer and aging research and personalized medicine in age-related diseases. The company is developing models and softwares to predict the efficacy of the various targeted drugs in oncology and extrapolated these methods to evaluate the possible geroprotective properties of the many drugs with known molecular targets. The mission of InSilico Medicine is to find working solutions to treat, cure and prevent age-related diseases and aging itself through excellence in knowledge management, machine learning and bioinformatics, relentless pursuit for new drug, omics and clinical outcomes data, development of reliable in silico drug screening methods, novel validation approaches and strong international partnerships in personalized medicine. This mission will be achieved within the regulatory frameworks as well as the legal and ethical boundaries and by working with the outstanding scientists, academic and medical institutions and pharmaceutical companies of impeccable credibility. For more information please visit http://www.InSilicoMedicine.com

Contact @ Insilico Medicine, Inc.:

InSilico Medicine, Inc.
Johns Hopkins University Eastern Campus
B301, 1101 East 33rd Street
Baltimore, MD 21218
Qinsong Zhu, PhD
Chief Operating Officer
+14107109674
zhu@insilicomedicine.com
This article was originally distributed on PRWeb. For the original version including any supplementary images or video, visit http://www.prweb.com/releases/InSilico/Medicine/prweb11904553.htm



 

Tuesday, May 27, 2014

Practical Applications of Aging Research for Drug Discovery

International symposium on geroprotectors:
Practical Applications of Aging Research for Drug Discovery 


Aging lies at the core of every age-related disease and affects every person on the planet. It represents an unbearable toll on the economies of the developed countries resulting in over two trillion dollars in direct medical costs, costs of caring and lost productivity in the US and EU alone. Yet, pharmaceutical companies fail to see the practical applications of aging research as many early experiments with drugs that held promise in slowing the aging processes resulted in commercial failures and write offs. Lack of business models, regulation and absence of a clear set of aging biomarkers make it difficult for large pharmaceutical companies to fully engage in aging research. Unlike other events that are geared towards academia or have a broad range of topics, this forum intends to focus on drug discovery and pharmaceuticals that may have a role in postponing the aging processes, preventing the age-related diseases and evaluating the effectiveness of various small molecules with geroprotective properties.

The event will showcase the research projects in aging research to the leaders of the pharmaceutical industry. The symposium will comprise into the three sessions relevant to the drug discovery companies. Each session will be chaired by the top expert in the field:

Session I: Predicting the activity of geroprotective drugs: in-silico screening, omics data analysis and rational drug design
Session II: Drugs with the potential geroprotective properties
Session III: Aging Biomarkers: how do we measure aging and geroprotective efficacy?
Session IV: Trends in Aging Research

www.AgingPharma.org