Recently it happened so that I translated one article devoted to the model, analyzing the investment market of regenerative medicine. I never thought of mathematical models but as work in it took a lot of time from me earlier, it was remembered to me for a long time! In this regard I had again one thought. Now there is in the world a tendency to the personalized medicine, a sequencing, genotyping. I think, that probably itsn`t need a Sequencing and genotyping of all and everyone , even in that case if it will be quite cheap (to 100 dollars and less). If we present a certain population from 100 people consisting in the family relations, genotyping or which sequencingneed to be carried out. If results 30 of them to us are known (has to be both gorizontal and vertical), probably, by means of mathematical model it will be possible to judge indirectly a genotype of each person from this population. And, I think that the error will be small. Probably the error can be reduced by data of the anamnesis of people. In difficult situations genotyping and a sequencing may be carry out. Results of usual clinical tests also most likely will reduce mistake level. It seems to me that it considerably can cut expenses of health care on researches of this sort and in general will increase quality of rendered medical services. I don't know, can do it thought it isn't new and still, I just write my opinion.
This blog is devoted to future of medicine, sceince, biogerontology and ageing, big data in biomedicine, robots.
Monday, January 27, 2014
Saturday, January 25, 2014
Mineral turnover test
I will a little recede from a subject of this blog though it indirectly concerns aging. But....
I would like to share to world the one idea while I didn't forget it, as many before. Imagine you suddenly you suspect at yourself of an organism surplus of any substance (lead or plumbum, arsenic, chrome, calcium, bismuth, chlorine or in general the raised content of radionuclides)...
Today in Russia there aren't enough doctors who in general reflect that the patient can have this or that poisoning with heavy metals or other substances. In the world for the last years was loud criminal cases about poisoning with radionuclides. It seems to me that probably it is much more of them. For example not to time didn't see the doctor in Russia who would direct at me the patient on research of a mineral turnover, poisonings with heavy metals, radionuclides. At the same time, there are many hearings that our environment is far from ideal, the percent of people accepting these or those preparations increased extremely (these are dietary supplements, household chemicals, contraceptives, in general drugs, products with preservatives, use of substances in agriculture). On the other hand - researches in this area will be most likely sensational and will have also political negative. In general there is no general complex dough for definition of the general mineral turnover of the person (there is no model of it test also). Mineral disorder may be cause calcification (calcification connective tissue in many human organs). One of the known companies in Russia on laboratory diagnostics (INVITRO) offers only few tests for detection of plumbum and an assessment of pollution of water and the soil which are extremely expensive. I think that the similar situation likely exists in Europe and America. Therefore work in this area probably has to be quite profitable and demanded. Also such methods will be useful to the proof of professional harm, professional diseases.
To read this text in Russian you may see to other my blog.Thanks for your attention! I hope this is article was useful for you.
I would like to share to world the one idea while I didn't forget it, as many before. Imagine you suddenly you suspect at yourself of an organism surplus of any substance (lead or plumbum, arsenic, chrome, calcium, bismuth, chlorine or in general the raised content of radionuclides)...
Today in Russia there aren't enough doctors who in general reflect that the patient can have this or that poisoning with heavy metals or other substances. In the world for the last years was loud criminal cases about poisoning with radionuclides. It seems to me that probably it is much more of them. For example not to time didn't see the doctor in Russia who would direct at me the patient on research of a mineral turnover, poisonings with heavy metals, radionuclides. At the same time, there are many hearings that our environment is far from ideal, the percent of people accepting these or those preparations increased extremely (these are dietary supplements, household chemicals, contraceptives, in general drugs, products with preservatives, use of substances in agriculture). On the other hand - researches in this area will be most likely sensational and will have also political negative. In general there is no general complex dough for definition of the general mineral turnover of the person (there is no model of it test also). Mineral disorder may be cause calcification (calcification connective tissue in many human organs). One of the known companies in Russia on laboratory diagnostics (INVITRO) offers only few tests for detection of plumbum and an assessment of pollution of water and the soil which are extremely expensive. I think that the similar situation likely exists in Europe and America. Therefore work in this area probably has to be quite profitable and demanded. Also such methods will be useful to the proof of professional harm, professional diseases.
To read this text in Russian you may see to other my blog.Thanks for your attention! I hope this is article was useful for you.
Saturday, January 18, 2014
ATTENTION GERONTOLOGISTS: CALL FOR PAPERS Drug Discovery International - promote your work to Big Pharma.
A consortium of the EU pharma companies launched an open access journal titled "Drug Discovery International" (http://www.drugdiscovery.ch/). For three years the major purpose of this journal was to help popularize research presented at the largest EU drug discovery conference, MipTec (http://www.miptec.ch/). Recently they got the resources to expand the journal's reach.
Thanks to one of the early evangelists of aging research within the large pharma, Dr. Bhupinder Bhullar at Novartis, the first issue of Drug Discovery will be focused on aging research. The deadline for submission is 1st of March.
Even though the journal does not have an impact factor, it has a unique promoter base comprised of the scientists and executives of large pharma.
This may be a good chance to feature your research to the many large pharmaceutical companies like Novartis, Roche, Actelion, AZN, Boehringer-Ingelheim, GSK and many others.
Also, MipTec just confirmed that they will be adding the Aging Forum (called World Symposium on Geroprotectors: Aging Research for Drug Discovery) in Basel, Switzerland (Sept 23-24) and the event will be Free to attend. The scientific program is being finalized, please keep in touch (http://www.miptec.ch/miptec2014/scientific-program/scientific-forum-descriptions.html ). Last year the event was attended by over 3,000 people.
www.drugdiscovery.ch
Friday, January 10, 2014
Theoretical physicists and biologists tap into investment analysis for regenerative medicine
Today the Biogerontology and Regenerative
Medicine Center (BRMC) announced the formation of a new analytical team
comprised of theoretical physicists, mathematicians, biologists and computer
scientists and the launch of the first modules of the Aging Intelligence
knowledge management system. The team’s first analytical model deemed “Analytical
Regenerative Medicine Industry Framework” (ISBN: 978-0-9912902-0-8) was
presented to a group of young scientists and medical doctors at the new office
in the city center of Moscow, who were invited to participate in editing and
contributing content to the new system.
"Governments
spend tens of billions annually on biomedical sciences and that knowledge is
disseminated freely on the Internet. Corporations spend as much as governments
or more, but do not publish their findings as actively. Predictive intelligence
is possible only by grooming data from a broad spectrum of sources and applying
machine-learning algorithms. By attracting the brightest minds in theoretical
physics, machine learning and computer science at the Moscow Institute of
Physics and Technology and pairing them with the experienced financiers from
the West, we are hoping to develop decision support systems that will help in
both investment planning and building roadmaps. We decided to take our first
shot at the regenerative medicine industry. ", said Andrey Garazha, the
director of the Biogerontology and Regenerative Medicine Center adjacent to the
Moscow Institute of Physics and Technology.
In partnership with the First Open
Institute for Regenerative Medicine for Young Scientists (FOIRMYS) and the UMA
Foundation, the BRMC performed a brief training session on the investment
fundamentals and announced the launch of a virtual investment simulation, where
young scientists are encouraged to compete on forming model investment
portfolios comprised of publically-traded companies in regenerative medicine as
well as the options on the stocks of these companies. The winners of the
competition will be offered positions at the BRMC.
"We salute
the efforts of this new team of young and ambitious scientists who are
developing sophisticated mechanisms and non-parametric analytical tools that do
not simply make predictions using historic trends, but incorporate data from a
variety of sources and react to the expected and unexpected research
breakthroughs to dynamically adjust both investment portfolios and research
pipelines. There are hedge funds in the US that profited from the genius of the
“quants” coming from the Moscow Institute of Physics and Technology and the fact
that some of the brilliant minds like Andrey Garazha will now turn their
attention on building models and knowledge management systems for dynamic
roadmaping of biomedical sciences.", said Alex Zhavoronkov, the director
of the Biogerontology Research Foundation in the UK and the adjunct professor
of the Moscow Institute of Physics and Technology.
Like computers in the 80s, the Internet in
the 90s and social networks in the past decade, biogerontology is the next big
frontier in investment potential. Not only it is the most worthy altruistic
cause that has the power to save billions of lives and take our quality of life
to the next level, it is the most promising area for capital preservation and
appreciation. The intelligent Big Data-driven approach to investment analysis
and decision making may not only assist with making better investment choices,
but also help advance the areas that maximize the longevity dividend and result
in cures rather than in treatments.
ABOUT
BRMC
Information analysis Center of Biogerontology
and Regenerative Medicine is based on Laboratory of Genetics of Aging and
Longevity of the Moscow Institute of Physics and Technology. The Center has
been constituted for aging research and development of innovative
life-extension technologies. Our partners are MIPT, “Northern”
Biopharmaceutical Cluster, FSCC PHOI n.a. Dmitry Rogachev and The The
Biogerontology Research Foundation.
The Centre is aimed to analyze anti-aging
technologies, to overview perspective research guidelines, to create databases
of aging biomarkers and geroprotectors, to design educational programs for
learning age-related processes and possible ways to control them. By organizing
seminars and conferences The Centre will promote development of international
collaboration in the areas of biogerontology.
ABOUT
UMA Foundation
The UMA Foundation is one of the leading
non-profit organizations in Russia that supports young scientists and promotes
scientific research. It was set up to revitalize Russian science and to encourage
renewed enthusiasm and passion for science and innovation – values that are
sometimes lacking in the younger generation. The foundation is governed by
leading academics, heads of universities and prominent business people. Among
its many other activities, the organization supports the “First Open Institute
for Regenerative Medicine for Young Scientists”, a rapidly growing volunteer
initiative that was set up by expatriate scientists as a means of providing
hundreds of young scientists with weekly lectures by leading international
thinkers as well as promoting goal-oriented scientific collaboration.
About
FOIRMYS
The First Open Institute for Regenerative
Medicine for Young Scientists (FOIRMYS) is a non-profit volunteer initiative
bringing together over a thousand enthusiast young scientists and physicians
interested in regenerative medicine. It was first organized by Alex Zhavoronkov, PhD in
collaboration with Sergey Yakovenko, PhD, Sergey Roumiantsev, PhD and Oleg
Korzinov in Moscow , where as part of the curriculum students participate in
practicums at “Altravita IVF, FRCCPH, FORCC,
Quantum Pharmaceuticals, Biopharmcluster “Northern” and Moscow Institute of Physics and Technology.
FOIRMYS provides regular weekly lectures by
the top academic and industry thought leaders, investors and regulators. The
list of presenters includes Paolo Macchiarini (Karolinska Institute), Alexey
Aravin (Caltech), Charles Cantor (Boston U, ex-director of the Human Genome
Project), Augustinus Bader (Leipzig University), top managers from Beijing
Genomics Institute, Malaysian Genome Resource Center, Indigo Capital Partners
and many others.
Members work in small teams comprised of
scientists and physicians on ambitious outlier projects in aging and
regenerative medicine with topics ranging from mineralization of connective
tissue, HGPS and regulation of endometriosis to industry overviews and
healthcare economics. The projects are coordinated in a crowdsourced
environment and rely heavily on popular tools like Facebook, Dropbox and Google
Apps. FOIRMYS developed a concept called “Personalized Medicine”, where
projects are centered around the problems of a single patient, who provides
samples and helps coordinate the project. Members also learn how to promote
their work, create personal science blogs (including Women in Science
initiative) and engage in industry outreach.
Participation in practical group projects
resulted in success stories including young scientists’ publications in
peer-reviewed journals, fellowships, participation in international
conferences, gainful employment of young scientists and international
collaborations.
Wednesday, January 8, 2014
UMA Foundation' press releases are seen now even by our friends in the USA!
Just want to share that news and link (
http://newsle.com/article/0/114206423/
) to my dear blog' reader. So nice! Fight aging is economic strategy and necessary future trend!
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