The neurodegeneration is one of the
features of aging and age-related disorders. Yet, only several
antiaging interventions are known to affect the processes of
neurodegeneration. Here we show that overexpression of the pro-longevity
gene D-GADD45 in Drosophila
neurons leads to a postponed manifestation of histological and
ultrastructural features of age-dependent neurodegeneration, such as
decrease in the packing density of neurons, increasing the degree of
neuron cytoplasmic vacuolization, and morphological defects of
mitochondrial cristae. Thus, the previously observed (Plyusnina,
Biogerontology 12: 211–226, 2011) life extending effect of D-GADD45 overexpression in the nervous system is associated with delayed neurodegeneration.
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