Monday, December 30, 2013

Biomedical progress rates as the new source of economic growth


The revolution in information technology has irreversibly changed our lives over the past two decades. However, advances in biomedicine stand poised to eclipse the social and economic effects of IT in the near future.

Biomedical innovations typically reach the mass market in much slower fashion than those from information technology. They follow a paradigm where neither demand, in the form of the consumer, nor supply, in the form of the innovator, can significantly accelerate the process.

However, in the near-term, unless the governments of the debt-laden developed countries make proactive policy changes, there is a possibility of lengthy economic decline and even collapse.

“John Maynard Keynes once said that in the long run we are all dead. Our model looks at the scenario, where some of us are alive in the long run. It also suggests that to grow the economy we need to make proactive policy changes and accelerate aging research as well as the propagation of biomedical advances from the laboratory into clinical practice.”, said Alex Zhavoronkov, the director of the Biogerontology Research Foundation.

“The contributions to life expectancy gains are blurred by the unhealthy behavior and environmental factors. However, in the near future we may see a revolution in longevity and we can either prepare for and accelerate the change or continue stimulating the economy using the Keynesian, monetarist or traditional neoclassical policies, run deeper into debt and face the dire consequences.”, he added.

“Governments, pension funds and individuals that have the adaptive life span and life expectancy expectations based on historic trends are likely to be unprepared for these paradigm shifts. We proposed a set of parameters that may be used in several models of economic growth to account for these scenarios both in the transitionary period and in the long run.”, said Maria Litovchenko, the research associate at the Biogerontology Research Foundation and the graduate student at the Ludwig Maximilian University of Munich.

The proposed model takes into account progress in the biomedical sciences, which in turn affects the size, growth and productivity of the population. In the model, the rate of biomedical progress is the sum of the rejuvenation rate, the rate at which the functions required to perform useful work that were lost to aging or disease are restored, and non-rejuvenating rate, which increases lifespan, but does not restore lost functions.

Joe Betts-lacroix, the executive director at Health Extension, said about the research: "A common concern about the dissemination of anticipated health-extending technologies worldwide is overpopulation.  However, only countries with low medical security have population growth.  Health-extending technologies will travel with overall medical technologies, and these will only reach countries as their incomes rise and their birth rates fall. In the western world, lower birth rates are automatically working to correct overpopulation. As reproductive lifespans increase (the maximum age at which women can give birth), women will wait longer to have their children, and population will continue to be regulated at a sustainable level."

The effects of population aging on economic growth remains a controversial topic in macroeconomics with conflicting schools of thought. While there are many models and simulations that account for population aging, new parameters introduced in this research may help enrich the models demonstrating both positive and negative effects of aging on the economy and help model scenarios that go beyond extending historic trends in longevity.

Commenting on the announcement Dr Joao Pedro de Magalhaes, researcher  at the University of Liverpool, said:With the graying of the world's population, and the massive resulting social and economic challenges, this type of work is very timely. A very important message from this work is that economists should take into account technological progress when making forecasts. This work also further emphasizes the absolute need for research on aging and rejuvenation to develop interventions that extends healthy lifespan which would result in unprecedented medical, social and economic gains.

“People are living longer, healthier lives, and this longevity boom is not going to stop any time soon. If we're to get to grips with the implications this will have for national economies, pension funds and society at large, we urgently need economic analysis of this trend. This paper is an insightful step in the right direction.”, - said Steven Burrill, CEO of Burrill & Co.

Notes to Editors
The authors of the study can be contacted at alex@biogerontology.org or maria.litovchenko@bg-rf.org.uk.



Thursday, November 14, 2013

Biogerontology reserch for Economic Growth in Developed Countries

Wow! What the  wonderful  article this bravery and clever group of scientist! I just want share it to you dear reader (and world!). It once again prove us that economical benefits of searching in gerontology, aging,  extending the productive lifespan and of course cryonics! So about this article:

Title: Biomedical Progress Rates as New Parameters for Models of Economic Growth in Developed Countries

Abstract: While the doubling of life expectancy in developed countries during the 20th century can be attributed mostly to decreases in child mortality, the trillions of dollars spent on biomedical research by governments, foundations and corporations over the past sixty years are also yielding longevity dividends in both working and retired population. Biomedical progress will likely increase the healthy productive lifespan and the number of years of government support in the old age. In this paper we introduce several new parameters that can be applied to established models of economic growth: the biomedical progress rate, the rate of clinical adoption and the rate of change in retirement age. The biomedical progress rate is comprised of the rejuvenation rate (extending the productive lifespan) and the non-rejuvenating rate (extending the lifespan beyond the age at which the net contribution to the economy becomes negative). While staying within the neoclassical economics framework and extending the overlapping generations (OLG) growth model and assumptions from the life cycle theory of saving behavior, we provide an example of the relations between these new parameters in the context of demographics, labor, households and the firm.

Figure: Employment rate by age group in the United States in 2012. The X-axis
represents age and the Y-axis represents the employment rate, calculated as the ratio of
employed population in the labor force to total population in the labor force.




I hope that you can try a bit your time for watching the full text. (International Journal of Environmental Research and Public Health with impact factor 1.998)

Monday, September 30, 2013

Project Mineralization connective tissue


I’d like to introduce to my dear blog’s  reader about our scientific project -Mineralization connective tissue. Our team of Russian scientists drills into the problem of age-related mineralization of the connective tissue. 

A 70-year old patient on the operating table and touch the aorta, the feeling may resemble touching an eggshell or sand paper. It is stiffer than the heart of a young person and the key reasons for this are the abundant calcium deposits in the connective tissue that accumulate with age. Calcification is a significant cause of morbidity and mortality because it is associated with atherosclerosis, chronic kidney disease and osteoporosis. 

The many factors leading to mineralization of the connective tissue include genetic and acquired diseases, inflammation, reactive oxygen species, but the major problem is that it occurs spontaneously during aging as calcium-containing molecules are trapped in the extracellular matrix and develop into apatite over time.

Despite its relative significance, compared to the many other areas of aging research, mineralization of the connective tissue is rarely mentioned in scientific publications and few teams are working on preventing or clearing out the extracellular aggregates.  There are currently no drugs to treat vascular calcification.

To address the problem, a multidisciplinary team of physicians, bioinformatitians, biochemists and physicists performed a comprehensive bioinformatics analysis of the many factors involved in mineralization, identified key molecular targets and proposed a list of possible drugs to address the issue. The next steps are clinical and experimental research that are supposed to make a great contribution to the design of new treatments for vascular calcification and the regenerative medicine.

The results of the study were accepted for publication by a high-impact journal in biogerontology “Rejuvenation Research” and will be published shortly and can be cited as “Mineralization of the connective tissue: a complex molecular process leading to age-related loss of function”, Anastasia Shindyapina, Garik V Mkrtchyan, Tatiana Gneteeva (I am), Sveatoslav Buiucli, M Kulka, B Tancowny, Alexander Aliper, Alexander Zhavoronkov, Rejuvenation Research, ahead of print. doi:10.1089/rej.2013.1475, http://online.liebertpub.com/doi/abs/10.1089/rej.2013.1475 , PMID 23902273

“Our team is consisted of active young scientists from the leading Russian universities and header Alex Zhavoronkov. I hope that together we can win pathological spontaneous calcification”, said Tatiana Gneteeva, student of 6 course of the First Moscow State Medical University. 


"Mineralization of connective tissue with age is one of the many aspects of aging that are examples of "accumulation of eventually pathogenic extracellular material", an issue that attracts too little attention within the academic community. The accumulation of advanced glycation endproducts (AGEs) and of mineral deposits both result in increased stiffness of connective tissue, impair homeostasis and contribute to a broad range of age-related diseases. Through comprehensive bioinformatic analysis of the many molecular processes involved in mineralization, Zhavoronkov's team have identified possible molecular interventions. Additionally they propose that mineralization and AGEs work in concert and should be addressed concurrently. Anastasia Shyndyapina, the lead author on the paper, recently presented this work at the SENS6 conference in Cambridge.", commented Dr. Aubrey de Grey, Chief Science Officer of SENS Research Foundation and International Adjunct Professor at the Moscow Institute of Physics and Technology (MIPT).
 

Figure  Role of proteins related to calcification in bone development and mineralization (red circles – pro-calcification factors, green circles – anti-calcification factors, black circles – related to calcification processes factors with unknown implication).

About FOIRMYS


The First Open Institute for Regenerative Medicine for Young Scientists (FOIRMYS) is a non-profit volunteer initiative bringing together over a thousand enthusiast young scientists and physicians interested in regenerative medicine. It was first organized by Alex Zhavoronkov, PhD in collaboration with Sergey Yakovenko, PhD, Sergey Roumiantsev, PhD and Oleg Korzinov in Moscow with support from Anna Chapman.
FOIRMYS provides regular weekly lectures by the top academic and industry thought leaders, investors and regulators. The list of presenters includes Paolo Macchiarini (Karolinska Institute), Alexey Aravin (Caltech), Charles Cantor (Boston U, ex-director of the Human Genome Project), Augustinus Bader (Leipzig University), top managers from Beijing Genomics Institute, Malaysian Genome Resource Center, Indigo Capital Partners and many others. As part of the curriculum students participate in practicums at “Altravita IVF, FRCCPH, FORCC, Quantum Pharmaceuticals, Biopharmcluster “Northern” and Moscow Institute of Physics and Technology.

Participation in practical group projects resulted in success stories including young scientists’ publications in peer-reviewed journals, fellowships, participation in international conferences, gainful employment of young scientists and international collaborations.








D. Rogachev Federal Research and Clinical Center for Pediatric
Hematology,. Oncology and Immunology






P.S. Thanks very much site www.labfairy.com for happy childhood ;) !!!


Saturday, August 3, 2013

The plan of development anti-age science


The maximum increase in life expectancy of the person is an ultimate goal not only gerontology, as a science about aging. Such directions as traditional medicine (therapeutic and intervention) and pharmacology (Geropharmacology, reception of various bioadditives and dietary supplements I too would refer to that), regenerative medicine and transplantology, a cryonics, methods of external factors modifying influence on life expectancy of the person (environment and climate, a food, psychological climate) also serve this purpose.  Besides, development of new technologies (computer, laboratory, diagnostic, etc.) will indirectly influence all above-mentioned. Today I would like to write some words  about how I imagine (some my reasons and ideas) the plan of a development anti-age science. 

1. FINANCING of researches directed on aging is key and probably one of the most important tasks. It is impossible without PROMOTING of information about reached achievements already now in this area. People have to understand really that, the mankind will step on new level after a win over aging. And financing has to have constant and increasing character and to have different sources.  I think that the program of "anti-aging " needs to be considered just as firm, which purpose not  to get  more and more money. As sources of finance can be used: creation of financial pyramids (offering information services in anti-aging and the latest medications, diagnostic services in gerontology), the state investment and grants, development of separate highly profitable projects (for example, projects on alternative energy sources), creation of bank uniting all scientists of the country (and not only), investment of certain individuals.The part of profit from realization of all energy resources of the country – would be sufficient for this purpose and it there would be a fast way of receiving funds for researches.
Besides for promoting creation of the hierarchical, ordered social network of one country uniting scientists is necessary or it is desirable all countries. The accession to this organization has to be obligatory and is initially state the adjustable. Subsequently the state could suggest this system to the commercial enterprises. Such social network would help to finish necessary information on aging to each scientist of the country or the world, promoted integration, to an exchange of experience and would involve in studying of aging of people pursuing science.What financing of the directions from presented will yield bigger result now which will allow to reach immortal life in the future?

2 A. Considering rates of scientific achievements of the last years in the field of gerontology medicine for an old age which will really prolong to the person life it will be created in 30-40 years. And geronscientists, which is now 60-65 years may be can’t get result of its work.
Probably activation of the financing of gerontology and in general science, its promoting, general interest of the population on a planet will increase rates of studying of this process, and period of receipt of an elixir of youth to be reduced, but all the same not all people to whom now 50-60 its years won't wait. But most of people, which will invest in projects on gerontology in the future, is 40 y.o. and older. Will they able receive results of investing in aging? Yes, but not all.
It seems to me, financing has to be directed first of all on a CRYONICS! I think that at excellent financing of this area successes will be in 5-10 years. Already now there are articles on modeling of freezing of the person, many experiences with the frozen bodies which confirm productivity of this method  were done. But I mean a freezing of the person not after his death -a freezing living people to whom really in the next some months threaten death. Cryonics has to be more important even than gerontology, as it while the only spare way ( or INSURANCE). By the way, medicine against an old age can be created much later, not in 40 years and through 100-200. Other questions:  Will be able cryonic people to be restored his mind to normal or future life? Even after a long anesthesia at operations people some time can behave enough not adequately … And I think that a cryonics will be even more traumatically. Now, a cryonics has high cost it has to be reduced the price or we are needed in other method for saving man.  For example  processes hibernation (lethargical sleep in human) at animals, or winter time for perennial plants have to more researching.  Medicamentous management this process will be cheaper and natural to the person.

2B. Also priority financing is deserved by ways which are directed on an intensification of scientific researches. It seems to me that system of giving and information extraction from scientific articles it has to be changed. Check on reliability and quality of article and scientific experiment has to be automatic. Extraction of the main thought and other material also has to be programmatically processed. Metaanalyses and reviews of scientific articles have to be formed independently, because of the quantity scientific articles grows every year, it will be and has to increase in the future. It will be promoted by change of the format of the scientific article. It everything will increase the volume of processed information. It would be very useful if some data from scientific articles (for example receptors, metabolites, other proteinaceous and not proteinaceous molecules) received and checked automatically on reliability were entered in programs on processing (for example the Metacore program) and the result was given in the form of schemes which would be analyzed by the person (or even the program automatically).
It everything would release a huge number of time at scientists, they could pay more attention to experiments though carrying out the last too has to be automated, more standardized and intensified. It would give could reduce time for information analysis, reduce the price of work, advance science much quicker. In my opinion it would be useful also if this program could completely dynamically and display biochemical process ontogenesis and filogenesis (hormonal changes eventually), and also to model future changes at addition of medicines dynamically.

2C. Just development gerontology, regenerative medicine and traditional medicine (which also includs of genetics ). These other directions too are important and without them a cryonics probably at all it doesn't make sense.  And certainly the main work also has to be conducted in these directions, along with cryonics and an intensification of scientific activity.  Probably even some projects on regenerative medicine (such as transplantation of organs, receiving blood of all groups (blood as organ) and regeneration of teeth, hair and other) can give financing for development and achievement of all other projects in regenerative medicine, in gerontology and traditional medicine. And it is possible to pay to them initial attention.
Reducing cost of sequencing and genotyping of DNA increase in number of these test will give the chance to improve achievements in general all DNA the analysis, will define DNA a profile of diseases that will make diagnostics of diseases of more exact, and treatment more directed. And development of a gene therapy (gerogenoterapiya) and a geropharmacology will add it.

3.  I think that, the studying of methods of external factors modifying influence on life expectancy of the person (environment and climate, a food, psychological climate) in comparison with other directions of achievement of immortality has smaller value then other. It is necessary, but it is no first and second things.

In conclusion I’d like to say that we don’t forget and that in parallel with increase in life expectancy of the person and development of scientific achievements in gerontology military intensity in the world will increase. Certainly break in gerontology in one country will lead to a big gap between people (states) having medicine for an old age for people (states) which this medicine won't have. And nevertheless, if we want to live and survive we have to win against aging. It will be a further step of development of evolution of mankind.





Thursday, July 11, 2013

Future doctor is scientist doctor!

I think that some main tendencies in medicine will come in the future. The first is more and more automation routine work of doctor. The doctor will treat bigger number of patients and its work will be connected not only with patients. He or she have to try a lot of time for studying of modern scientific literature and also conduct researches in medicine himself (especially in group, command other specialist). Furthermore, next doctor will closely work with such experts as programmers, biophysics, bioengineers, pharmacologists. Professional physicians will have to great number communications with other world doctors and exchange experience with them. Of course it concerns more invasive interventions and surgery. Computer technology for this purpose will stormy evolve. I think that investing in it is very perspective.

Not secret that the majority of patients present time is more senior than 50 years. Most likely that a medical care after some 20-30 years will more quality. It will increase life expectancy of each person. Then other problem arises - the number of patients of advanced age in future will be huge!!! Now we see that the retirement age grows in many  European countries. New extremely interesting and actually
book "The Ageless Generation" (How advances in biomedicine will transform the global economy) of Russian-american bioengineer, scientist Alex Zhavoronkov is rather fully opened this theme.

In the future the same specialized clinics for persons of old age will be able offer medical care better than usual hospitals, such clinics probably will be widespread. And in medical university more attention will be paid to gerontology teaching. Now, in my university we don't study it at all.

Important that symptoms of diseases at the elderly are expressed less or can be absent in general, and the disease proceeds differently than at persons of young and middle age. For example features of an acute appendicitis at old people: pains are usually insignificant, temperature or normal, or is slightly increased. Tension of muscles of a belly wall can not be at all. Symptoms of irritation of a peritoneum are expressed poorly or absolutely are absent. The quantity of leukocytes in blood normal or is slightly increased. These features depend on fall of resilience of an organism of old people to an infection therefore even at the expressed destructive changes in a shoot attacks of an acute appendicitis proceed without many typical symptoms. Because of poorly expressed symptoms patients seldom address for medical care at the beginning of a disease and arrive already in the presence of peritonitis or appendicular infiltrate. Therefore at an examination of elderly patients the medicine has to have more specific tests for defining diseases. Now some of such usually using tests can not meet requirements of medicine for elderly patients.

Here is some greatest Russian, American, Britain, Italian specialists in aging area:

Brian K. Kennedy 
Judith Campisi, 
Dr. Nir Barzilai
Jan Vijg, 
Elizabeth H. Blackburn, Carol W. Greider, Jack W. Szostak , The Nobel Prize in Physiology or Medicine 2009 for the discovery of  "how chromosomes are protected by telomeres and the enzyme telomerase" (Telomeres delay ageing of the cell).
Robert J. Shmookler Reis
Claudio Franceschi 
Andrei Gudkov 
Elena G. Pasyukova
Vera Gorbunova
Khavinson Vladimir
Aleksei Moskalev

And also I would like recommend to You  some sites about biogerontology:

How to Become a Biogerontologist
Ever wondered about how much money governments worldwide spend on aging research and specifically on YOUR AREA OF INTEREST? Would you like to see the answer to these questions with graphs, charts and publications? One of the best tools for aging research spotted.

Сonclusion: most likely the medicine of the future will be very closely connected with gerontology.

We know that main causes of death in the developed and developing countries including Russia is cardiovascular diseases and a cancer (a cancer most often meets at elderly and old), so we can say that is causes accompanying aging. Among diseases on aging also considerable diabetes, hypercholesterolemia, arterial hypertension, Alzheimer's disease. Atherosclerosis as a cardiovascular disease is often attract attention of many scientists now and past, in the future most likely this problem will be solved or negative consequences of atherosclerosis simply will be treated therapeutic. Whether there will be needed a stenting and aorto coronary bypass surgery? Probably not. But, i think, surgeons and experts in the field of transplantology, and also doctors of methods of visualization will be exact necessary.

As for me, I and my command of young scientists (bioinformaticly, bioengineering, medical profiles ) we are engaged in studying of process of a calcification connective tissue  (a special case of a mineralization of process). Why calcification? - Calcification of vessels occurs at each person and she becomes most expressed at people is more senior than 50 years. This process accompanies atherosclerosis - the main reason of cardiovascular diseases. We very much hope that we will be able to find a way which will stop a active pathological calcification of vessels with aging! And probably thanks to it the problem of atherosclerosis will be solved? But it is a subject of the other my blog ...

Nowdays in main Russian medical university more active students want to be no only doctor but the scientist doctor. For me very pleasantly that among them there are a lot of girls, young scientists (and I am one of them:). And we have  even own Russian Society of the Woman in Science!
Future doctor it first of all the doctor who can understand base tendencies of development of medicine, is able to react to them, which to advance their development in time. One, most important of which is gerontology. Considering the aforesaid, interstingly, what medical residency you will going to choose in the future?