Monday, January 27, 2014

Sequencing and genotyping

Recently it happened so that I translated one article devoted to the model, analyzing the investment market of regenerative medicine. I never thought of mathematical models but as work in it took a lot of time from me earlier, it was remembered to me for a long time! In this regard I had again one thought. Now there is in the world a tendency to the personalized medicine, a sequencing, genotyping. I think, that probably itsn`t need a Sequencing and genotyping of all and everyone , even in that case if it will be quite cheap (to 100 dollars and less). If we present a certain population from 100 people consisting in the family relations, genotyping or which sequencingneed to be carried out. If results 30 of them to us are known (has to be both gorizontal and vertical), probably, by means of mathematical model it will be possible to judge indirectly a genotype of each person from this population. And, I think that the error will be small. Probably the error can be reduced by data of the anamnesis of people. In difficult situations genotyping and a sequencing may be carry out. Results of usual clinical tests also most likely will reduce mistake level.  It seems to me that it considerably can cut expenses of health care on researches of this sort and in general will increase quality of rendered medical services. I don't know, can do it thought it isn't new and still, I just write my opinion.

If you have other point of view, please give a comment below. It would be very interesting to me.

Saturday, January 25, 2014

Mineral turnover test

I will a little recede from a subject of this blog though it indirectly concerns aging.  But....

I would like to share to world  the one idea while I didn't forget it, as many before. Imagine you suddenly you suspect at yourself of an organism surplus of any substance (lead or plumbum, arsenic, chrome, calcium, bismuth, chlorine or in general the raised content of radionuclides)...
Today in Russia there aren't enough doctors who in general reflect that the patient can have this or that poisoning with heavy metals or other substances. In the world for the last years was loud criminal cases about poisoning with radionuclides. It seems to me that probably it is much more of them. For example not to time didn't see the doctor in Russia who would direct at me the patient on research of a mineral turnover, poisonings with heavy metals, radionuclides. At the same time, there are many hearings that our environment is far from ideal, the percent of people accepting these or those preparations increased extremely (these are dietary supplements, household chemicals, contraceptives, in general drugs, products with preservatives, use of substances in agriculture). On the other hand - researches in this area will be most likely sensational and will have also political negative. In general there is no general complex dough for definition of the general mineral turnover of the person (there is no model of it test also). Mineral disorder may be cause calcification (calcification connective tissue in many human organs). One of the known companies in Russia on laboratory diagnostics (INVITRO) offers only few tests for detection of plumbum and an assessment of pollution of water and the soil which are extremely expensive. I think that the similar situation likely exists in Europe and America. Therefore work in this area probably has to be quite profitable and demanded. Also such methods will be useful to the proof of professional harm, professional diseases.

To read this text in Russian you may see to other my blog.Thanks for your attention! I hope this is article was useful for you.

Saturday, January 18, 2014

ATTENTION GERONTOLOGISTS: CALL FOR PAPERS Drug Discovery International - promote your work to Big Pharma.



A consortium of the EU pharma companies launched an open access journal titled "Drug Discovery International" (http://www.drugdiscovery.ch/). For three years the major purpose of this journal was to help popularize research presented at the largest EU drug discovery conference, MipTec (http://www.miptec.ch/). Recently they got the resources to expand the journal's reach.

Thanks to one of the early evangelists of aging research within the large pharma, Dr. Bhupinder Bhullar at Novartis, the first issue of Drug Discovery will be focused on aging research. The deadline for submission is 1st of March.

Even though the journal does not have an impact factor, it has a unique promoter base comprised of the scientists and executives of large pharma.
This may be a good chance to feature your research to the many large pharmaceutical companies like Novartis, Roche, Actelion, AZN, Boehringer-Ingelheim, GSK and many others.

Also, MipTec just confirmed that they will be adding the Aging Forum (called World Symposium on Geroprotectors: Aging Research for Drug Discovery) in Basel, Switzerland (Sept 23-24) and the event will be Free to attend. The scientific program is being finalized, please keep in touch (http://www.miptec.ch/miptec2014/scientific-program/scientific-forum-descriptions.html ). Last year the event was attended by over 3,000 people.


www.drugdiscovery.ch

Friday, January 10, 2014

Theoretical physicists and biologists tap into investment analysis for regenerative medicine


 

Today the Biogerontology and Regenerative Medicine Center (BRMC) announced the formation of a new analytical team comprised of theoretical physicists, mathematicians, biologists and computer scientists and the launch of the first modules of the Aging Intelligence knowledge management system. The team’s first analytical model deemed “Analytical Regenerative Medicine Industry Framework” (ISBN: 978-0-9912902-0-8) was presented to a group of young scientists and medical doctors at the new office in the city center of Moscow, who were invited to participate in editing and contributing content to the new system.

"Governments spend tens of billions annually on biomedical sciences and that knowledge is disseminated freely on the Internet. Corporations spend as much as governments or more, but do not publish their findings as actively. Predictive intelligence is possible only by grooming data from a broad spectrum of sources and applying machine-learning algorithms. By attracting the brightest minds in theoretical physics, machine learning and computer science at the Moscow Institute of Physics and Technology and pairing them with the experienced financiers from the West, we are hoping to develop decision support systems that will help in both investment planning and building roadmaps. We decided to take our first shot at the regenerative medicine industry. ", said Andrey Garazha, the director of the Biogerontology and Regenerative Medicine Center adjacent to the Moscow Institute of Physics and Technology.

In partnership with the First Open Institute for Regenerative Medicine for Young Scientists (FOIRMYS) and the UMA Foundation, the BRMC performed a brief training session on the investment fundamentals and announced the launch of a virtual investment simulation, where young scientists are encouraged to compete on forming model investment portfolios comprised of publically-traded companies in regenerative medicine as well as the options on the stocks of these companies. The winners of the competition will be offered positions at the BRMC. 

"We salute the efforts of this new team of young and ambitious scientists who are developing sophisticated mechanisms and non-parametric analytical tools that do not simply make predictions using historic trends, but incorporate data from a variety of sources and react to the expected and unexpected research breakthroughs to dynamically adjust both investment portfolios and research pipelines. There are hedge funds in the US that profited from the genius of the “quants” coming from the Moscow Institute of Physics and Technology and the fact that some of the brilliant minds like Andrey Garazha will now turn their attention on building models and knowledge management systems for dynamic roadmaping of biomedical sciences.", said Alex Zhavoronkov, the director of the Biogerontology Research Foundation in the UK and the adjunct professor of the Moscow Institute of Physics and Technology.

Like computers in the 80s, the Internet in the 90s and social networks in the past decade, biogerontology is the next big frontier in investment potential. Not only it is the most worthy altruistic cause that has the power to save billions of lives and take our quality of life to the next level, it is the most promising area for capital preservation and appreciation. The intelligent Big Data-driven approach to investment analysis and decision making may not only assist with making better investment choices, but also help advance the areas that maximize the longevity dividend and result in cures rather than in treatments.

 “We are glad that for the ambitious quest of solving aging in-silico will commence on the powerful ASUS hardware. ASUSTek is one of the world’s leaders in high-performance IT solutions and in Russia we support Dr. Zhavoronkov’s lab at the largest pediatric oncology center. Andrey Garazha and some of his team members have long been the ASUS Fellows in bioinformatics and medical information technology.”, said Alex Kim, the director of ASUSTek in Russia. 


ABOUT BRMC

Information analysis Center of Biogerontology and Regenerative Medicine is based on Laboratory of Genetics of Aging and Longevity of the Moscow Institute of Physics and Technology. The Center has been constituted for aging research and development of innovative life-extension technologies. Our partners are MIPT, “Northern” Biopharmaceutical Cluster, FSCC PHOI n.a. Dmitry Rogachev and The The Biogerontology Research Foundation.

The Centre is aimed to analyze anti-aging technologies, to overview perspective research guidelines, to create databases of aging biomarkers and geroprotectors, to design educational programs for learning age-related processes and possible ways to control them. By organizing seminars and conferences The Centre will promote development of international collaboration in the areas of biogerontology.

ABOUT UMA Foundation

The UMA Foundation is one of the leading non-profit organizations in Russia that supports young scientists and promotes scientific research. It was set up to revitalize Russian science and to encourage renewed enthusiasm and passion for science and innovation – values that are sometimes lacking in the younger generation. The foundation is governed by leading academics, heads of universities and prominent business people. Among its many other activities, the organization supports the “First Open Institute for Regenerative Medicine for Young Scientists”, a rapidly growing volunteer initiative that was set up by expatriate scientists as a means of providing hundreds of young scientists with weekly lectures by leading international thinkers as well as promoting goal-oriented scientific collaboration.

About FOIRMYS


The First Open Institute for Regenerative Medicine for Young Scientists (FOIRMYS) is a non-profit volunteer initiative bringing together over a thousand enthusiast young scientists and physicians interested in regenerative medicine. It was first organized by Alex Zhavoronkov, PhD in collaboration with Sergey Yakovenko, PhD, Sergey Roumiantsev, PhD and Oleg Korzinov in Moscow , where as part of the curriculum students participate in practicums at “Altravita IVF, FRCCPH, FORCC, Quantum Pharmaceuticals, Biopharmcluster “Northern” and Moscow Institute of Physics and Technology.
FOIRMYS provides regular weekly lectures by the top academic and industry thought leaders, investors and regulators. The list of presenters includes Paolo Macchiarini (Karolinska Institute), Alexey Aravin (Caltech), Charles Cantor (Boston U, ex-director of the Human Genome Project), Augustinus Bader (Leipzig University), top managers from Beijing Genomics Institute, Malaysian Genome Resource Center, Indigo Capital Partners and many others.

Members work in small teams comprised of scientists and physicians on ambitious outlier projects in aging and regenerative medicine with topics ranging from mineralization of connective tissue, HGPS and regulation of endometriosis to industry overviews and healthcare economics. The projects are coordinated in a crowdsourced environment and rely heavily on popular tools like Facebook, Dropbox and Google Apps. FOIRMYS developed a concept called “Personalized Medicine”, where projects are centered around the problems of a single patient, who provides samples and helps coordinate the project. Members also learn how to promote their work, create personal science blogs (including Women in Science initiative) and engage in industry outreach.

Participation in practical group projects resulted in success stories including young scientists’ publications in peer-reviewed journals, fellowships, participation in international conferences, gainful employment of young scientists and international collaborations.


Wednesday, January 8, 2014

UMA Foundation' press releases are seen now even by our friends in the USA!

Just want to share that news and link ( http://newsle.com/article/0/114206423/ ) to my dear  blog' reader. So nice! Fight aging is economic strategy and necessary future trend!