Thursday, April 30, 2020

Frost & Sullivan recognizes Insilico as innovation leader in drug discovery

April 30, 2020 - Today Insilico Medicine has announced that Frost & Sullivan named it as a top innovator in drug discovery, highlighting it as a technology pioneer in this industry. 
Generative AI is an emerging technology in both chemistry and biology. Insilico Medicine has been working in these areas since 2015, and holds the critical intellectual property in generative biology for generation of synthetic biological data, target discovery, and cross-tissue and cross-species analysis; generative chemistry for generation of novel molecules, and generative medicine for prediction of clinical trials outcomes. According to recent legal opinions, drugs generated using AI may be classified as being invented by AI. Insilico published its first peer-reviewed papers in this area in 2016, and multiple experimental proofs of concept for JAK3 and DDR1 kinases with many other targets being pursued internally. 
The company generated and released a range of molecules targeting COVID-19 protease generated in 4 days. Generative biology technology for the target discovery has been developed and utilized internally since 2015, and the first landmark experiment in target discovery is expected to be published in 2020. 
"Insilico Medicine is a true innovator and visionary in the application of AI for novel product discovery and precision medicine. The deep generative models based on neural networks, Generative Tensorial Reinforcement Learning (GENTRL) models developed by the company generates and tests new leads with breakthrough productivity over conventional industry benchmarks." said Amol Jadhav, PhD, Industry Analyst at Frost & Sullivan. "Frost & Sullivan is pleased to include Insilico Medicine in recognition of its pioneering research, validated full stack technology, growing pipeline of molecules, extensive portfolio and commitment toward high-profile partnerships".
"I would like to congratulate my global teams on their tireless efforts and excellence in both AI and drug discovery that are now recognized by Frost & Sullivan. For five years we made bets on disruptive technologies with very limited resources and often struggled. But now these bets paid off and we are getting a new software suite we refer to as the Pharmaceutical Operating System to be released this year," said Alex Zhavoronkov, PhD, co-founder and CEO of Insilico Medicine. 
Insilico Medicine has been at the forefront of the competition and has established collaborations and partnerships with over 150 academic and industry partners worldwide. 
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About Frost & Sullivan
For over five decades, Frost & Sullivan has become world-renowned for its role in helping investors, corporate leaders and governments navigate economic changes and identify disruptive technologies, Mega Trends, new business models and companies to action, resulting in a continuous flow of growth opportunities to drive future success. http://www.frost.com
About Insilico Medicine
Since 2014 Insilico Medicine is focusing on generative models, reinforcement learning (RL), and other modern machine learning techniques for the generation of new molecular structures with the specified parameters, generation of synthetic biological data, target identification, and prediction of clinical trials outcomes. Recently, Insilico Medicine secured $37 million in series B funding. Since its inception, Insilico Medicine raised over $52 million, published over 80 peer-reviewed papers, applied for over 25 patents, and received multiple industry awards. Website http://insilico.com/
Media Contact

For further information, images or interviews, please contact: ai@insilico.com

Tuesday, April 28, 2020

Insilico Medicine enters into a collaboration research with Astellas Pharma Inc. to apply novel generative artificial intelligence system for a conventionally challenging target family

      Insilico Medicine has announced that it has entered into a research collaboration agreement with Astellas Pharma Inc. to utilize Insilico Medicine's novel generative artificial intelligence technology aimed at accelerating development of candidates against a conventionally challenging target family. This collaboration builds on AI platform developed by Insilico Medicine and will apply Astellas' expertise in drug discovery. 


 

"Astellas is at the forefront of innovation in drug discovery and is seen as a leader in developing and acquiring new emerging technology. This collaboration will exploit the capabilities of our entire generative chemistry platform which experienced exponential increases in performance and quality over the past few years. We are very happy to collaborate with some of the most intelligent and sophisticated scientists in the world on a very interesting target which, has no known examples to learn from, and our platform utilizing meta learning, zero-shot generative reinforcement learning, and genetic algorithms, holds a lot of promise," Alex Zhavoronkov, PhD, founder, and CEO of Insilico Medicine.
Under the terms of the agreement, Insilico Medicine will receive an upfront payment and milestones. Insilico Medicine will closely collaborate with Astellas, which will synthesize, optimize and characterize the molecules generated using artificial intelligence. 
"We are excited to collaborate with Astellas' experienced drug discovery team in applying our state-of-the-art AI technologies in molecular generation for this high-value previously challenging target family. Insilico Medicine is a world leader in artificial intelligence for drug discovery and the original inventor of the many approaches. We believe that this collaboration with one of the most innovative pharmaceutical companies will help deliver the much needed drugs to the patients sooner," said Jimmy Yen-Chu Lin, PhD, CEO of Insilico Medicine Taiwan.
Earlier this year, Insilico Medicine's generative chemistry technology was highlighted by the MIT Technology Review as a breakthrough of 2020, and is actively used to generate novel chemistry for the key SARS-CoV-2 proteins.

About Astellas Pharma Inc

About Insilico Medicine Since 2014 Insilico Medicine is focusing on generative models, reinforcement learning (RL), and other modern machine learning techniques for the generation of new molecular structures with the specified parameters, generation of synthetic biological data, target identification, and prediction of clinical trials outcomes. Recently, Insilico Medicine secured $37 million in series B funding. Since its inception, Insilico Medicine raised over $52 million, published over 80 peer-reviewed papers, applied for over 25 patents, and received multiple industry awards.

Wednesday, April 15, 2020

Insilico collaborates with Boehringer Ingelheim on AI system for target discovery

Insilico enters into a research collaboration with Boehringer Ingelheim to apply novel generative artificial intelligence system for discovery of potential therapeutic targets




Wednesday, 15th of April, 2020 (6:00AM, Hong Kong) - Insilico Medicine is pleased to announce that it has entered into a research collaboration with Boehringer Ingelheim to utilize Insilico's generative machine learning technology and proprietary Pandomics Discovery Platform with the aim of identifying potential therapeutic targets implicated in a variety of diseases.
"Insilico Medicine is very impressed with the Research Beyond Borders group at Boehringer Ingelheim capabilities in the search of potential drug targets. In this collaboration, Insilico will provide additional AI capabilities to discover novel targets for a variety of diseases to benefit the patients worldwide. We are very happy to partner with such an advanced group" said Alex Zhavoronkov, PhD, founder, and CEO of Insilico Medicine.
"We believe that Insilico's exclusive Pandomics platform will provide huge boost to our ability to explore and identify drug targets. We look forward to using AI to significantly improve the drug discovery process and contribute to human health." said from Dr. Weiyi Zhang, Head of External Innovation Hub, Boehringer Ingelheim Greater China. 
In September 2019, Insilico Medicine announced a $37 million round led by prominent biotechnology and AI investors.
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About Insilico Medicine
Since 2014 Insilico Medicine is focusing on generative models, reinforcement learning (RL), and other modern machine learning techniques for the generation of new molecular structures with the specified parameters, generation of synthetic biological data, target identification, and prediction of clinical trials outcomes. Since its inception, Insilico Medicine raised over $52 million, published over 70 peer-reviewed papers, applied for over 20 patents, and received multiple industry awards.
Media Contact
For further information, images or interviews, please contact:
About Boehringer Ingelheim 
Improving the health of humans and animals is the goal of the research-driven pharmaceutical company Boehringer Ingelheim. The focus in doing so is on diseases for which no satisfactory treatment option exists to date. The company therefore concentrates on developing innovative therapies that can extend patients' lives. In animal health, Boehringer Ingelheim stands for advanced prevention. 
Family-owned since it was established in 1885, Boehringer Ingelheim is one of the pharmaceutical industry's top 20 companies. Some 50,000 employees create value through innovation daily for the three business areas human pharmaceuticals, animal health and biopharmaceuticals. In 2018, Boehringer Ingelheim achieved net sales of around 17.5 billion euros. R&D expenditure of almost 3.2 billion euros, corresponded to 18.1 per cent of net sales. 
As a family-owned company, Boehringer Ingelheim plans in generations and focuses on long-term success. The company therefore aims at organic growth from its own resources with simultaneous openness to partnerships and strategic alliances in research. In everything it does, Boehringer Ingelheim naturally adopts responsibility towards mankind and the environment. 
More information about Boehringer Ingelheim can be found on http://www.boehringer-ingelheim.com or in our annual report: http://annualreport.boehringer-ingelheim.com
About Boehringer Ingelheim Partnering Day 2020
Boehringer Ingelheim Partnering Day 2020 will be held in Shanghai on Nov 3. It aims to engage and collaborate with Chinese innovative start-ups or individuals and inspire local partners to gear up innovation. Boehringer Ingelheim Innovation Prize is part of Boehringer Ingelheim Partnering Day. It is the first innovation prize in biomedicine sponsored by a multinational pharmaceutical company in China. Boehringer Ingelheim is calling for startups or individuals who have innovative ideas or business plans to participate.
Please click the link below to sign up online!