Wednesday, March 30, 2022

Ulta Beauty & Haut.AI partner to bring new era of beauty and healthcare with AI-powered hyper-personalization

 

Ulta Beauty and Haut.AI partner to develop disruptive, inclusive, personalized artificial intelligence engine for skin health and beauty


Today, Haut.AI, a leading research and development company specializing in next-generation artificial intelligence for skincare and longevity, announced a strategic partnership with Ulta Beauty, the largest beauty retailer in the United States. 

The Ulta Beauty and Haut.AI partnership is rooted in a shared goal  to co-create innovative digital skincare tools and offer beauty enthusiasts even greater experiences. Together, the two leaders will enhance skin analysis technology with enriched data, skin algorithms, simulations and improved recommendations.

“Our teams are laser focused on imagining – and reimagining – the most engaging guest experiences across every Ulta Beauty touchpoint,” said Prama Bhatt, chief digital officer, Ulta Beauty. “As industry leaders, we are thrilled to bring forward innovative solutions that serve our guests and cannot wait to see how our partnership with Haut.AI will deliver for guests as we marry our passions for personalization, data-driven technology and beautiful possibilities.”

Since its inception in 2018, Haut.AI has focused on developing and applying next-generation artificial intelligence technologies for skincare, beauty and longevity. The innovative leader supports advanced R&D activities of major global skincare brands and manufacturers, particularly in new product development, testing and collection of claims, and consumer studies.

Ulta Beauty and Haut.AI’s highly experienced, technical and product teams share a vision to help beauty enthusiasts achieve short-term skincare goals, in addition to preserving and improving skin long term. Together, the teams will co-create disruptive, exciting ways to hyper-personalize daily skincare routines.

“An AI-based system that can identify skin issues is not a novelty today. We recognize the next big step is how consumers experience these systems,” said Anastasia Georgievskaya, chief executive officer, Haut.AI. “Our solution is highly accurate and with Ulta Beauty, we will create an AI engine to address consumer skin needs early to prevent deterioration, while tailoring recommendations to individual preferences spanning texture, smell, brand values and preferred ways to shop. Who said science-backed, AI-powered skincare can’t be fun?” 

As part of the partnership, Haut.AI’s will build new capabilities and utilize its inclusive skin scan technology which has been rigorously tested and validated on a curated image dataset. . In turn, Ulta Beauty will enrich Haut.AI’s recommendation engine with consumer insights and product preferences to create a next-generation omnichannel shopping experience.

About Haut.AI

Haut.AI is a leading global artificial intelligence company specializing in skincare and longevity. It combines advanced deep learning techniques for machine vision, deep generative models for synthetic data generation, and reinforcement learning with expert human dermatologists, nutritionists, and biogerontologists for the development of advanced hyper-personalized recommendation engines for beauty, skincare, and longevity.

Haut.AI is headquartered in Estonia, the digital hub of the European Union. It prides itself on supporting diversity and inclusion by developing AI that works equally well for different skin types and skin colors, as well as developing novel techniques for recognizing bias. The company’s SaaS solution currently serves global skincare brands, retailers and contract research organizations in 27 different markets.

For further inquiries please contact press@haut.ai and visit our website https://haut.ai.

Friday, March 25, 2022

Insilico Medicine Applauded by Frost & Sullivan for Enabling Rapid and Cost-Effective Drug Discovery and Development with Its Pharma.AI Platform

 The Pharma.AI platform combining deep generative models (GAN), reinforcement learning (RL), transformers, and other modern machine learning techniques enables the identification of novel targets, generation of novel molecules non-existent in the chemical space, and prediction of outcomes for clinical trials.



SAN ANTONIO, Mar. 15, 2022 /PRNewswire/ — Based on its recent analysis of the global artificial intelligence (AI)-enabled drug discovery industry, Frost & Sullivan recognizes Insilico Medicine with the 2021 Entrepreneurial Company of the Year Award in the global AI-enabled drug discovery industry.

Pharma.AI, the end-to-end AI-enabled drug discovery and development platform of Insilico, addresses challenges that touch on chemistry, biology, and digital medicine. The combined AI and drug discovery expertise enable the identification of novel targets, generation of novel molecules non-existent in the chemical space, and prediction of outcomes for clinical trials. The AI solutions and verified automated AI platform streamline research and development (R&D) efforts, remodel therapeutics discovery, and advance precision medicine. In addition, these solutions accelerate research workflow, leading to rapid and cost-effective discovery and development.

According to Supriya Lala Kundu, industry analyst at Frost & Sullivan, “Insilico’s AI platforms integrate GANs, reinforcement learning (RL), and transformer neural networks to automate multi-targeting, polypharmacolocogy, and holistic diseases assessment. The company is working on AI-powered robotics to create driverless drug discovery as it moves towards advanced technologies and 100% automation.”

PandaOmics is one of the AI-enabled engines of Pharma.AI which integrates proteomics, transcriptomics, and other data types with advanced AI algorithms. PandaOmics supports target disease identification and supports research and target identification for different diseases. The AI-powered platform provides complex algorithms that recommend relevant novel drug target hypotheses in a few days rather than several months, significantly reducing drug discovery timelines.

Insilico Medicine also utilizes multiple algorithms that rapidly evaluate the targets for possible binding sites to address the challenge of transitioning from target to small molecules with desired properties. Chemistry42, a small molecule generation engine of Pharma.AI platform with 30 algorithms, identifies the right pockets and designs a range of molecules that do not exist in the chemical space within a few days. In addition, the engine enables the filtering from billions of generated molecules to identify easy-to-synthesize and inexpensive-to-develop molecules with the highest success potential. Chemistry42TM , a cloud and on-premise hardware-agnostic and scalable platform that can be licensed and tested by clients, delivers new actionable drug-like molecules in days.

“Insilico leverages its proprietary AI-driven platforms to effectively address the challenges of identifying accurate targets, developing novel molecular structures with desired parameters, and predicting clinical trial outcomes. Its deep technical expertise facilitates accelerated and cost-efficient novel therapeutic compound design and innovative drug discovery for cancer, fibrosis, infectious diseases, and aging-related diseases. For example, in 2021, Insilico initiated the first-in-human study of a potentially first-in-class drug candidate with a novel target for fibrosis. Notably, the company completed the entire discovery process from target discovery to preclinical candidate nomination within 18 months on a budget of $2.6 million. Furthermore, Insilico nominated two preclinical candidates with a novel molecular structure for anemia of chronic kidney disease and inflammatory bowel disease within 12 months using its AI engine. Such milestones thoroughly validate Insilico’s AI platform as robust and effective,” Kundu explained further.


In addition to the two engine mentioned above that have already been launched as software, InClinicoTM , another AI-powered engine in development by Insilico which could provide prediction of outcomes for clinical trials has exciting prospects as well. With its strong overall performance, growing partnerships, focus on innovation, and expertise in end-to-end drug discovery and development, Insilico Medicine earns Frost & Sullivan’s 2021 Entrepreneurial Company of the Year Award in the global AI-enabled drug discovery industry.

Each year, Frost & Sullivan presents this award to the company that has demonstrated excellence in devising and implementing a strong growth strategy. The recipient has shown strength in terms of innovation in products and technologies, leadership in customer value, and speed in response to market needs. The award looks at the emerging market participants in the industry and recognizes their best practices that are positioned for future growth excellence.

Frost & Sullivan Best Practices Awards recognize companies in various regional and global markets for demonstrating outstanding achievement and superior performance in leadership, technological innovation, customer service, and strategic product development. Industry analysts compare market participants and measure performance through in-depth interviews, analyses, and extensive secondary research to identify best practices in the industry.


About Insilico Medicine

Insilico Medicine, an end-to-end AI-driven drug discovery and development company, is connecting biology, chemistry, and clinical trials analysis using next-generation AI systems. Insilico Medicine has developed AI platforms that utilize deep generative models, reinforcement learning, transformers, and other modern machine learning techniques to discover novel targets and to design novel molecular structures with desired properties. Insilico Medicine is delivering breakthrough solutions to discover and develop innovative drugs for cancer, fibrosis, immunity, central nervous system (CNS) diseases and aging-related diseases. For more information, visit www.insilico.com.


Thursday, March 10, 2022

Insilico Medicine enters research collaboration with the University of Zurich to apply Insilico's generative Artificial Intelligence platform for the discovery of potential therapeutics for Cystinosis

 - Cystinosis is a rare genetic disease affecting 1 in 100,000-200,000 live births and poses a lifelong risk to those affected. Cystinosis slowly destroys the body's organs including the kidneys, eyes, thyroid, muscles, liver, pancreas, gonads, and brain.


- There are currently no curative treatments for cystinosis.


- The Mechanisms of Inherited Kidney Disorders (MIKADO) group at the University of Zurich (UZH) and Insilico Medicine will be working together to identify, rank, and annotate novel drug targets to identify potential therapeutics for cystinosis.





NEW YORK and ZURICHMarch 9, 2022 /PRNewswire/ -- The MIKADO group, a translational team at the UZH focused on generating evidence-driven insights to understand and treat rare inherited kidney diseases, and Insilico Medicine, an end-to-end Artificial Intelligence (AI)-driven drug discovery company, today announced a research and development collaboration designed to accelerate the discovery of transformative novel therapeutics for cystinosis. The duration of the initial research collaboration will be one year.

Specifically, the MIKADO group will leverage its multi-omics databank obtained from preclinical models and cystinosis-based cell models by using Insilico's comprehensive novel target discovery AI platform PandaOmics to identify cellular and molecular pathways that drive life-threatening complications in cystinosis patients. The MIKADO group will analyse disease-relevant targetable pathways and utilize Insilico's proprietary algorithms to generate libraries of small molecule compounds that are expected to be validated in preclinical models and cystinosis cell systems using disease-relevant screening technologies developed by the MIKADO group at the UZH.

"I am thrilled by the collaboration between MIKADO and Insilico. With the power of artificial intelligence-driven, systems biology-based drug discovery, we intend to accelerate the analysis and discovery of drug targets, with the goal of bringing novel breakthrough medicines to cystinosis patients while decreasing costs and increasing probabilities of success," said Olivier Devuyst, MD, Ph.D., head of MIKADO group at the UZH.

"Cystinosis is a commonly neglected disease with large unmet need. We are pleased to partner with MIKADO at the UZH combining the best of PandaOmics target discovery AI and human intelligence for the potential benefit of cystinosis patients worldwide," said Alex Zhavoronkov Ph.D., CEO of Insilico Medicine.

Using innovative preclinical models and disease-relevant phenotype screening, we aim to validate novel drug targets for diseases which no cure has been found. Ultimately, we want to improve the quality of life for those affected by the disease and bring tangible hope to thousands of cystinosis patients around the world," said Alessandro Luciani Ph.D., senior scientist and team leader at MIKADO.

For more information, images, or interviews, please contact media@insilicomedicine.com

About Cystinosis

Cystinosis—one of a family of approximately 70 rare inborn diseases of the metabolism known as lysosomal storage diseases that collectively affect 1 in 5,000 live births—is caused by inactivating mutations in the CTNS gene encoding the proton-driven transporter cystinosin, which exports cystine from the lysosome. Its functional loss leads cystine to accumulate within the lysosome of tissues across the body, culminating in severe multiorgan dysfunctions that affect primarily the brain, eyes, liver, muscles, pancreas, and kidneys. Fanconi syndrome is the first manifestation of cystinosis, usually presenting within the first year of life and characterized by the early and severe dysfunction of the kidney proximal tubule, most often complicated by chronic kidney disease and life-threatening manifestations. In their second to third decade of life, patients with cystinosis can also develop hypothyroidism, hypogonadism, diabetes, myopathy, and deterioration of fine vision and decline of the central nervous system. Beyond supportive care, the only available FDA-approved strategy to counteract cystine storage is the oral administration of cysteamine, which allows cystine to exit from the lysosomes. However, cysteamine treatment is hampered by side effects and poor tolerance, and it does not prevent nor treat PT dysfunction and kidney disease. Therefore, there is an urgent need to develop novel therapeutics for this devastating disease.

About Insilico Medicine

Insilico Medicine, an end-to-end artificial intelligence (AI)-driven drug discovery company, is connecting biology, chemistry, and clinical trials analysis using next-generation AI systems. The company has developed AI platforms that utilize deep generative models, reinforcement learning, transformers, and other modern machine learning techniques to discover novel targets and to design novel molecular structures with desired properties. Insilico Medicine is delivering breakthrough solutions to discover and develop innovative drugs for cancer, fibrosis, immunity, central nervous system (CNS) diseases and aging-related diseases.

For more information, please visit www.insilico.com. Follow us on LinkedIn

About MIKADO group

The group "Mechanisms of Inherited Kidney Disorders" led by Prof. Dr. med. Olivier Devuyst and Dr. Alessandro Luciani is investigating the fundamental mechanisms that cause inherited kidney disorders affecting the epithelial cells lining the kidney tubule, leading to chronic kidney disease (CKD) ¾ one of the fastest growing disease worldwide and a major public health burden. Combining human genetic studies with innovative model organisms (e.g., rat and zebrafish) and physiologically relevant cellular systems, and integrating them with OMICs technologies and cutting-edge screening assays, we are applying the knowledge gained from fundamental studies of epithelial cell biology to develop disease biomarkers and novel therapeutics that might potentially improve the care for patients with genetic disorders affecting the kidney and other organs. The MIKADO group has established a zebrafish platform to perform high-throughput and high-content screens for kidney disease therapeutics, and a biochemical profiling platform adapted to microsamples (high-throughput screens coupled to clinical studies or metabolic studies in model organisms).

For more information, please visit https://www.physiol.uzh.ch/en/research/institutegroups/grdevuyst.html. Follow us on Twitter

SOURCE Insilico Medicine