Friday, June 28, 2019

Life data economics: calling for new models to assess the value of human data

After the collapse of the blockchain bubble a number of research organisations are developing platforms to enable individual ownership of life data and establish the data valuation and pricing models
June 27, 2019 - Recent advances in artificial intelligence and precision medicine led to the emergence of new businesses that trade and process human health data. Most pharmaceutical companies are acquiring large volumes of clinical and other data for research and marketing purposes. However, there are few examples of companies turning this data into new therapeutic products and it is difficult to estimate the potential benefits stemming from a specific data type or a combination. Unlike in finance, where there are established methods for pricing anything from money to complex derivative securities, there are no established models for estimating the value of human life data. 
One of the ways to develop the data economics models is to establish a marketplace for human life data where patients can take control of their data and profit from either the direct sale of this data, or share in the profits generated using this data. In the paper titled "The Advent of Human Life Data Economics" in Cell  Trends in Molecular Medicine, George Church, a professor at Harvard Medical School and the co-founder of Nebula Genomics and Alex Zhavoronkov, the founder of Insilico Medicine present a concept of data economics with the multiple parameters impacting the value of human life data. The paper provides an overview of the blockchain-enabled platforms for exchanging medical records after the burst of the blockchain bubble. 
"In addition to these hack-resistant public ledgers, we have rapidly improving tools for whole genome sequencing and homomorphic encryption queries to deliver better privacy so that many people can finally benefit from knowing and owning their own genomes," said George Church, Ph.D., Professor of Genetics at Harvard Medical School and a founding member of the Wyss Institute for Biologically Inspired Engineering at Harvard.
The healthcare industry has increasingly adopted blockchain technologies for life data management to improve the quality, efficiency, and transparency of the health care system. The growth of electronic patient records has led to the artificial intelligence-based data analysis that can provide unprecedented insights into human health. Adopting big data technologies in the healthcare sector carries many benefits, but it also raises some barriers and challenges. 
With the continued growth of the blockchain technology within the healthcare system, data security, patient data privacy and the ability to manage consent and share data benefits with the patients, has become more vital than ever. Storing and processing medical data in the cloud, or the closed ecosystem, which prevents its illegal usage, blockchain technology can increase patients' engagement by allowing them to make profit from the initial sale of the data.
"George Church pioneered many areas of science and technology and inspired three generations of scientists in multiple areas. This paper presents a call for new models for valuing human life data with the many proposed parameters. Leading economists and mathematicians are invited to collaborate on data pricing models in the context of human health. When human life data can be considered to be an asset in the context of financial accounting and can be easily traded, we are likely to see an explosion of data-driven biomedical innovation," said Alex Zhavoronkov, Ph.D, Founder and CEO of Insilico Medicine. 
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For further information, images or interviews, please contact:
Contact: Klug Gehilfe 
ai@pharma.ai
Please follow the link to read the article: 
About Insilico Medicine, Inc
Insilico Medicine is an artificial intelligence company headquartered in Rockville, with R&D and management resources in Belgium, Russia, UK, Taiwan, and Korea sourced through hackathons and competitions. The company and its scientists are dedicated to extending human productive longevity and transforming every step of the drug discovery and drug development process through excellence in biomarker discovery, drug development, digital medicine, and aging research.
Insilico pioneered the applications of the generative adversarial networks (GANs) and reinforcement learning for generation of novel molecular structures for the diseases with a known target and with no known targets. In addition to working collaborations with the large pharmaceutical companies, the company is pursuing internal drug discovery programs in cancer, dermatological diseases, fibrosis, Parkinson's Disease, Alzheimer's Disease, ALS, diabetes, sarcopenia, and aging. Through a partnership with LifeExtension.com, the company launched a range of nutraceutical products compounded using the advanced bioinformatics techniques and deep learning approaches. It also provides a range of consumer-facing applications including Young.AI.

In 2017, NVIDIA selected Insilico Medicine as one of the Top 5 AI companies in its potential for social impact. In 2018, the company was named one of the global top 100 AI companies by CB Insights. In 2018 it received the Frost & Sullivan Award accompanied with the industry brief. Website: http://insilico.com/
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Wednesday, June 26, 2019

Danica Chen to present at the 6th Aging Research for Drug Discovery Forum in Basel

Wednesday, June 26, 2019 - Today Insilico Medicine, a biotechnology company developing the end-to-end drug discovery pipeline utilizing the next generation artificial intelligence, and the Scheibye-Knudsen Lab, University of Copenhagen, announce the presentation of Danica Chen, Ph.D., Associate Professor of Metabolic Biology, Nutritional Sciences & Toxicology at the University of California, Berkeley, at the 6th Aging Research, Drug Discovery, and AI Forum during the Basel Life Congress, September 10-12, 2019, Basel, Switzerland.

Recent advances in stem cell biology highlight a mitochondrial metabolic checkpoint that is essential for stem cells to return to the quiescent state. This process is critically regulated by several sirtuin family members. As the loss of stem cell quiescence results in the depletion of the stem cell pool and compromised tissue regeneration, deciphering the molecular mechanisms that regulate the mitochondrial metabolic checkpoint in stem cells will increase our understanding of tissue homeostasis and how it becomes dysregulated under pathological conditions and during aging. More broadly, this knowledge is instrumental for understanding the maintenance of cells that convert between quiescence and proliferation to support their physiological functions.
"A comprehensive understanding of the epigenetics of stem cell aging is central to the basic biology of aging and pivotal to the realization of the extent to which aging-associated conditions are reversible and, ultimately, to the therapeutic potential of the biology of aging. Promising Alzheimer's drug trials failed recently. It is plausible that it is too late to start the treatment and it has gone to the point of no return. It is more urgent than ever to understand the reversibility of aging-associated conditions," said Danica Chen, Ph.D., Associate Professor of Metabolic Biology, Nutritional Sciences & Toxicology at the University of California, Berkeley.
"I am really thrilled that professor Danica Chen is joining us in Basel. Professor Chen has made many seminal discoveries in the field of aging, particularly focusing on how metabolism impacts and is impacted by the aging process. Recently, she has moved into stem cell maintenance, a field that may be particularly important for aging research. I am therefore really happy that professor Chen is coming to Basel," said Morten Scheibye-Knudsen, MD, Ph.D., University of Copenhagen.
"Over the last 5 years, the "Aging & Drug Discovery" and "AI for Healthcare" forums have been leading events at BaselLife, attracting hundreds of delegates from over 50 countries. This year, we are combining the 2 platforms into a 3 day-event titled "the 6th Aging, AI and Drug Discovery Forum" to explore the convergence of these 2 cutting edge disciplines. Under the program leadership of Professor Morten Scheibye-Knudsen and Dr. Alex Zhavoronkov, with distinguished scientists and industry experts in the field, we look forward to exploring breakthroughs for this great healthcare need for the planet," said Dr. Bhupinder Bhullar, Chair, Innovation Forum program committee, Basel Life 2019. 
"The 6th annual Aging Research, Drug Discovery, and AI Forum at Basel Life will have a fresh program featuring some of the most prominent scientists and industry players in aging and longevity research covering the theory, applications and convergence of these three exciting areas," said Alex Zhavoronkov, Ph.D., Founder, and CEO of Insilico Medicine, Inc.
The 6th Aging Research for Drug Discovery Forum Basel will bring together leaders in the aging, longevity, and drug discovery field, to describe the latest progress in the molecular, cellular and organismal basis of aging and the search for interventions. Furthermore, the forum will include opinion leaders in AI to discuss the latest advances of this technology in the biopharmaceutical sector and how this can be applied to interventions. This event intends to bridge academic and commercial research and foster collaborations that will result in practical solutions to one of humanity's most challenging problems: aging. The Forum will be held in Basel, Switzerland, September 10-12, 2019. 
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For further information, images or interviews, please contact: 
Ola Popova ola@pharma.ai
About Danica Chen
Danica Chen is an Associate Professor of Metabolic Biology, Nutritional Sciences & Toxicology at the University of California, Berkeley; a member of Berkeley Stem Cell Center, and a member of QB3 Consortium in Lifespan Extension. She was a Searle Scholar, an Ellison Scholar, a Kavli Fellow, and a Hellman Fellow. Dr. Chen received a Ph.D. in molecular and cell biology from the University of California and obtained postdoctoral training in biology at the Massachusetts Institute of Technology. Her research aims to understand the molecular and cellular mechanisms underlying aging-associated conditions and define which aspects of age-associated conditions are reversible. Recent studies from her lab have revealed mitochondrial stress as a cause of stem cell exhaustion and tissue degeneration during aging. Dr.Chen identified mitochondrial stress resistance programs that become dysregulated in aged stem cells, and demonstrated that these programs can be targeted to improve survival and regenerative capacity of aged stem cells. These findings give hope to targeting age-associated dysregulated cellular protective programs, such as the pathways regulated by NAD+- dependent enzymes sirtuins, to reverse stem cell aging, tissue degeneration and dysfunction.
About Insilico Medicine, Inc
Insilico Medicine is an artificial intelligence company headquartered in Rockville, with R&D and management resources in Belgium, Russia, UK, Taiwan, and Korea sourced through hackathons and competitions. The company and its scientists are dedicated to extending human productive longevity and transforming every step of the drug discovery and drug development process through excellence in biomarker discovery, drug development, digital medicine, and aging research.
In 2017, NVIDIA selected Insilico Medicine as one of the Top 5 AI companies in its potential for social impact. In 2018, the company was named one of the global top 100 AI companies by CB Insights. In 2018 it received the Frost & Sullivan 2018 North American Artificial Intelligence for Aging Research and Drug Development Award accompanied with the industry brief. Brief company video: https://www.youtube.com/watch?v=l62jlwgL3v8. 
Official website: http://insilico.com
About the Scheibye-Knudsen Laboratory
The growing proportion of the elderly population represents an increasing socioeconomic challenge, not least because of age-associated diseases. It is therefore increasingly pertinent to find interventions for age-associated diseases such as Alzheimer's, Parkinson's and cardiovascular diseases. Although the cause of aging is currently unknown accumulation of damage to our genome, the DNA, may be a contributing factor.
In the Scheibye-Knudsen lab we try to understand the cellular and organismal consequences of DNA damage with the aim of developing interventions. We have discovered that DNA damage leads to changes in certain metabolites and that replenishment of these molecules may alter the rate of aging in model organisms. These findings suggest that normal aging and age-associated diseases may be malleable to similar interventions. The hope is to develop interventions that will allow everyone to live healthier, happier and more productive lives.
Laboratory website: http://scheibye-knudsen.com/
About the University of Copenhagen
With over 40,000 students and more than 9,000 employees, the University of Copenhagen is the largest institution of research and education in Denmark and among the highest ranked universities in Europe. The purpose of the University - to quote the University Statute - is to 'conduct research and provide further education to the highest academic level'. Approximately one hundred different institutes, departments, laboratories, centres, museums, etc., form the nucleus of the University.
About Basel Life 2019 
Aging Research for Drug Discovery Forum description 
In this symposium, leaders in the aging, longevity, and drug discovery field will describe the latest progress in the molecular, cellular and organismal basis of aging and the search for interventions. Furthermore, the forum will include opinion leaders in AI to discuss the latest advances of this technology in the biopharmaceutical sector and how this can be applied to interventions. This event intends to bridge academic and commercial research and foster collaborations that will result in practical solutions to one of humanity's most challenging problems: aging. A panel of thought-leaders will give us their cutting edge reports on the latest progress in our quest to extend the healthy lifespan of everyone on the planet. 
Conference Official Website: https://www.basellife.org/2019.html
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Tuesday, June 25, 2019

Insilico Medicine to present at the 2nd LEAF Annual Event: Ending Age-Related Diseases 2019

Tuesday, June 25, 2019 - Insilico Medicine, a biotechnology company developing the end-to-end drug discovery pipeline utilizing the next generation artificial intelligence, will present its latest results in modern and next-generation AI for drug discovery and productive longevity at the Ending Age-Related Diseases 2019 in New York, on July 11. Insilico Medicine is also very proud to be one of the sponsors of the event this year, which will give a unique opportunity to present our brand and to communicate with the most skilled people of ageing research. Ending Age-Related Diseases 2019 will take place in the heart of New York City at the Frederick P. Rose Auditorium, Cooper Union.
The biological aging clocks, using deep learning techniques, were first presented were first presented by the scientists at Insilico Medicine in 2015 and published in 2016. They can be used in a broad range of applications in the pharmaceutical industry, spanning target identification, drug discovery, data economics and synthetic patient data generation. The presentation will cover the applications of these aging clocks in actuarial science for prediction of mortality and health hazards.

Life Extension Advocacy Foundation has been very active at promoting research on aging around the world since its creation, and in 2018, hosted its own conference, in order to support the growth of the industry. This led to the creation of Ending Age-Related Diseases, a conference that brings together industry leaders of the ageing research for two action-packed days of biotechnology in the heart of New York City at the Cooper Union. The goal of this conference is to foster multidisciplinary collaboration in order to accelerate the development of next-generation drugs and therapies that directly target the processes of aging and thus have the potential to prevent and cure age-related diseases.


 "As the global population is aging, morbidity from chronic age-related diseases is rapidly increasing. The drugs and therapies that could modify the way we age by addressing the root causes of aging would help us to prevent the onset of age-related diseases and extend the healthy period of life. However, in order to have these innovations developed in time, and to assess their effectiveness in the clinic, we need good methods of measuring biological aging. This is why we'll begin the conference with a section on the biomarkers of aging before exploring advances in the fundamental studies of aging and discussing potential interventions. The list of confirmed speakers includes renowned researchers and visionaries, such as Aubrey de Grey (SENS Research Foundation), George Church (Harvard Medical School), Judith Campisi (the Buck Institute), Maria A. Blasco (CNIO), Ronald Kohanski (NIA), Morgan Levine (Yale Center for Research on Aging), Kelsey Moody (Ichor Therapeutics), Andrei Gudkov (Roswell Park Comprehensive Cancer Center), and many others," said Elena Milova, LEAF Board Member and director of the conference
"We are happy to present our latest research at the Ending Age-related diseases 2019, which gathers the key scientists of the ageing research. The topic of biomarkers of ageing is rapidly gaining popularity, and we are happy to be at the leading edge of this research and one of the innovation drivers in the area," said Alex Zhavoronkov, Ph.D., Founder, and CEO of Insilico Medicine.

###
For further information, images or interviews, please contact:
Contact: Klug Gehilfe ai@pharma.ai
For press accreditation to the conference Ending Age-Related Diseases 2019, please contact Elena Milova elena@lifespan.io

About Insilico Medicine, Inc
Insilico Medicine is an artificial intelligence company headquartered in Rockville, with R&D and management resources in Belgium, Russia, UK, Taiwan, and Korea sourced through hackathons and competitions. The company and its scientists are dedicated to extending human productive longevity and transforming every step of the drug discovery and drug development process through excellence in biomarker discovery, drug development, digital medicine, and aging research.
Insilico pioneered the applications of the generative adversarial networks (GANs) and reinforcement learning for generation of novel molecular structures for the diseases with a known target and with no known targets. In addition to working collaborations with the large pharmaceutical companies, the company is pursuing internal drug discovery programs in cancer, dermatological diseases, fibrosis, Parkinson's Disease, Alzheimer's Disease, ALS, diabetes, sarcopenia, and aging. Through a partnership with LifeExtension.com, the company launched a range of nutraceutical products compounded using the advanced bioinformatics techniques and deep learning approaches. It also provides a range of consumer-facing applications including Young.AI.
In 2017, NVIDIA selected Insilico Medicine as one of the Top 5 AI companies in its potential for social impact. In 2018, the company was named one of the global top 100 AI companies by CB Insights. In 2018 it received the Frost & Sullivan 2018 North American Artificial Intelligence for Aging Research and Drug Development Award accompanied with the industry brief. Brief company video: https://www.youtube.com/watch?v=l62jlwgL3v8. For more information: http://insilico.com/
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Friday, June 21, 2019

Reason to present at the 6th Aging Research for Drug Discovery Forum in Basel

Friday, June 21, 2019 - Today Insilico Medicine, a biotechnology company developing the end-to-end drug discovery pipeline utilizing the next generation artificial intelligence, and the Scheibye-Knudsen Lab, University of Copenhagen, announce the presentation of Reason, Co-founder and CEO of Repair Biotechnologies; Founder and writer of Fight Aging!, at the 6th Aging Research, Drug Discovery, and AI Forumduring the Basel Life Congress, September 10-12, 2019, Basel, Switzerland.

Repair Biotechnologies is one of a growing family of companies focused on reversing aspects of the progression of aging through repair of the deeper underlying causes of aging and age-related disease. Repair Biotechnologies is developing two distinct approaches for treatment. One approach is the regeneration of the involuted thymus, in order to restore active tissue involved in the maturation of T cells. Atrophy of this tissue with age reduces the supply of new T cells and contributes significantly to immunosenescence and inflammaging. Thymic regrowth is well demonstrated in mice to at least partially restore the flow of recent thymic emigrant cells and reverse the loss of competent T cells in older individuals. The master regulator of thymic growth and T cell maturation activity, FOXN1, is well known and well characterized, making this a very promising target for modern gene therapy techniques.
The second approach is the reversal of atherosclerotic lesions through intervention at the macrophage, rather than at blood cholesterol levels. Atherosclerosis is a leading cause of death worldwide, with no therapy yet shown in human trials to achieve more than a minor reversal of existing lesions. The development of lesions is driven by macrophage dysfunction, induced particularly by oxidized lipids, and resulting in the foam cell phenotype. Macrophages can be made resilient to the inflammatory, foam cell fate, or given the capacity to more aggressively dispose of atherosclerotic lesion contents. What is known of the mechanisms of atherosclerosis marks this as a promising category for the development of interventions.
"It is critical for our industry to do better at translation of promising research. The thymus is one of the keys to rejuvenation of the aged adaptive immune system, while atherosclerosis kills perhaps a sixth of everyone - and yet all too many of the best potential approaches to therapy, in either case, have languished untended for years in the valley of death between lab and clinic," said Reason, Co-founder and CEO of Repair Biotechnologies; Founder and writer of Fight Aging!.
"I am really grateful that Reason from Repair Biotechnologies is joining us in Basel. Repair Biotechnologies is a recently founded company that deals with two main issues that occur with aging: cardiovascular disease and immunological dysfunction. I therefore very much look forward to learning about their approach and making progress within these critical subjects," said Morten Scheibye-Knudsen, MD, Ph.D., University of Copenhagen.
"Over the last 5 years, the "Aging & Drug Discovery" and "AI for Healthcare" forums have been leading events at BaselLife, attracting hundreds of delegates from over 50 countries. This year, we are combining the 2 platforms into a 3 day-event titled "the 6th Aging, AI and Drug Discovery Forum" to explore the convergence of these 2 cutting edge disciplines. Under the program leadership of Professor Morten Scheibye-Knudsen and Dr. Alex Zhavoronkov, with distinguished scientists and industry experts in the field, we look forward to exploring breakthroughs for this great healthcare need for the planet," said Dr. Bhupinder Bhullar, Chair, Innovation Forum program committee, Basel Life 2019. 
"The 6th annual Aging Research, Drug Discovery, and AI Forum at Basel Life will have a fresh program featuring some of the most prominent scientists and industry players in aging and longevity research covering the theory, applications and convergence of these three exciting areas," said Alex Zhavoronkov, Ph.D., Founder, and CEO of Insilico Medicine, Inc.
The 6th Aging Research for Drug Discovery Forum Basel will bring together leaders in the aging, longevity, and drug discovery field, to describe the latest progress in the molecular, cellular and organismal basis of aging and the search for interventions. Furthermore, the forum will include opinion leaders in AI to discuss the latest advances of this technology in the biopharmaceutical sector and how this can be applied to interventions. This event intends to bridge academic and commercial research and foster collaborations that will result in practical solutions to one of humanity's most challenging problems: aging. The Forum will be held in Basel, Switzerland, September 10-12, 2019. 
###
For further information, images or interviews, please contact: 
Ola Popova ola@pharma.ai
About Reason
Reason is co-founder and CEO of Repair Biotechnologies, a biotech startup working on means of rejuvenation of the thymus and reversal of atherosclerosis. He is the founder and writer of Fight Aging!, which has been a leading voice in the longevity biotechnology and patient advocacy communities for more than fifteen years. Reason is also an active angel investor in the rejuvenation biotechnology space, and has for many years led and aided non-profit fundraising for academic research into rejuvenation via repair of molecular damage.
About Repair Biotechnologies
Repair Biotechnologies is a longevity company with the mission to develop and bring to the clinic therapies that significantly improve human healthspan through targeting the causes of age-related diseases and aging itself. Founded in 2018 by Reason and Bill Cherman, Repair Biotechnologies is developing therapies with the goals of reversing atherosclerosis and atrophy of the thymus. 
This year Repair Biotechnologies raised $2.15 million seed round, to accelerate the preclinical development of its pipeline of drugs targeting thymus regeneration, cancer, and atherosclerosis. The $2.15 million in funding was led by Jim Mellon, the billionaire investor and Chairman of Juvenescence Ltd. Also participating in the round are Emerging Longevity Ventures, Thynk Capital, and SENS Research Foundation.
About Fight Aging!
Fight Aging! began as a longevity science and advocacy blog in 2004, an outgrowth of a similar initiative called the Longevity Meme that ran as a news service and online resource from 2001 to 2011. Fight Aging! continues in its stead. Both projects originate with Reason, a patient advocate with a long-standing interest in the development of health- and longevity-enhancing medical technologies.
The Fight Aging! mission remains the same as it was at the outset: to encourage the development of medical technologies, lifestyles, and other means that will help people live comfortably, healthily, and capably for as long as they desire, well beyond the current limits of mortality.
Official website: https://www.fightaging.org/
About Insilico Medicine, Inc
Insilico Medicine is an artificial intelligence company headquartered in Rockville, with R&D and management resources in Belgium, Russia, UK, Taiwan, and Korea sourced through hackathons and competitions. The company and its scientists are dedicated to extending human productive longevity and transforming every step of the drug discovery and drug development process through excellence in biomarker discovery, drug development, digital medicine, and aging research.
In 2017, NVIDIA selected Insilico Medicine as one of the Top 5 AI companies in its potential for social impact. In 2018, the company was named one of the global top 100 AI companies by CB Insights. In 2018 it received the Frost & Sullivan 2018 North American Artificial Intelligence for Aging Research and Drug Development Award accompanied with the industry brief. Brief company video: https://www.youtube.com/watch?v=l62jlwgL3v8. 
Official website: http://insilico.com
About the Scheibye-Knudsen Laboratory
The growing proportion of the elderly population represents an increasing socioeconomic challenge, not least because of age-associated diseases. It is therefore increasingly pertinent to find interventions for age-associated diseases such as Alzheimer's, Parkinson's and cardiovascular diseases. Although the cause of aging is currently unknown accumulation of damage to our genome, the DNA, may be a contributing factor.
In the Scheibye-Knudsen lab we try to understand the cellular and organismal consequences of DNA damage with the aim of developing interventions. We have discovered that DNA damage leads to changes in certain metabolites and that replenishment of these molecules may alter the rate of aging in model organisms. These findings suggest that normal aging and age-associated diseases may be malleable to similar interventions. The hope is to develop interventions that will allow everyone to live healthier, happier and more productive lives.
Laboratory website: http://scheibye-knudsen.com/
About the University of Copenhagen
With over 40,000 students and more than 9,000 employees, the University of Copenhagen is the largest institution of research and education in Denmark and among the highest ranked universities in Europe. The purpose of the University - to quote the University Statute - is to 'conduct research and provide further education to the highest academic level'. Approximately one hundred different institutes, departments, laboratories, centres, museums, etc., form the nucleus of the University.
About Basel Life 2019 
Aging Research for Drug Discovery Forum description In this symposium, leaders in the aging, longevity, and drug discovery field will describe the latest progress in the molecular, cellular and organismal basis of aging and the search for interventions. Furthermore, the forum will include opinion leaders in AI to discuss the latest advances of this technology in the biopharmaceutical sector and how this can be applied to interventions. This event intends to bridge academic and commercial research and foster collaborations that will result in practical solutions to one of humanity's most challenging problems: aging. A panel of thought-leaders will give us their cutting edge reports on the latest progress in our quest to extend the healthy lifespan of everyone on the planet. Conference Official Website: https://www.basellife.org/2019.html


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Wednesday, June 19, 2019

Insilico Medicine to present at the Ageing, Health & Rejuvenation Nature Conference

Wednesday, June 19, 2019 - Insilico Medicine, a biotech company developing the end-to-end drug discovery pipeline utilizing the next generation artificial intelligence, will present its latest results in modern and next-generation AI for drug discovery and productive longevity at the Ageing, Health & Rejuvenation Nature Conference in Rotterdam, on June 23rd. Insilico Medicine is also very proud to be one of the bronze sponsors of the event this year, which will give a unique opportunity to present our brand and to communicate with the most skilled people of ageing research. The event is jointly organised by Erasmus MC, Nature, Nature Medicineand Nature Reviews Molecular Cell Biology. 
The conference brings together experts from diverse fields of research that explore the mechanisms of ageing and rejuvenation, from the perspective of genetics and epigenetics, cellular quality control and senescence, stem cells, metabolism and brain function. The aim of the conference is to foster interactions and stimulate discussion of recent and unpublished advances in our understanding of the ageing process, and to explore new therapeutic opportunities for the rejuvenation and preservation of organs and tissues to extend healthspan.
"We are happy to present our latest research at the Ageing, Health & Rejuvenation Nature Conference, which gathers the key scientists of the ageing research. The topic of machine learning implementation in drug discovery is rapidly gaining popularity, and we are happy to be at the leading edge of this research and one of the innovation drivers in the area," said Alex Zhavoronkov, Ph.D., Founder, and CEO of Insilico Medicine.
###
For further information, images or interviews, please contact:
Contact: Klug Gehilfe ai@pharma.ai
About Insilico Medicine, Inc
Insilico Medicine is an artificial intelligence company headquartered in Rockville, with R&D and management resources in Belgium, Russia, UK, Taiwan, and Korea sourced through hackathons and competitions. The company and its scientists are dedicated to extending human productive longevity and transforming every step of the drug discovery and drug development process through excellence in biomarker discovery, drug development, digital medicine, and aging research. Insilico pioneered the applications of the generative adversarial networks (GANs) and reinforcement learning for generation of novel molecular structures for the diseases with a known target and with no known targets. In addition to working collaborations with the large pharmaceutical companies, the company is pursuing internal drug discovery programs in cancer, dermatological diseases, fibrosis, Parkinson's Disease, Alzheimer's Disease, ALS, diabetes, sarcopenia, and aging. Through a partnership with LifeExtension.com, the company launched a range of nutraceutical products compounded using the advanced bioinformatics techniques and deep learning approaches. It also provides a range of consumer-facing applications including Young.AI.
In 2017, NVIDIA selected Insilico Medicine as one of the Top 5 AI companies in its potential for social impact. In 2018, the company was named one of the global top 100 AI companies by CB Insights. In 2018 it received the Frost & Sullivan 2018 North American Artificial Intelligence for Aging Research and Drug Development Award accompanied with the industry brief. Brief company video: https://www.youtube.com/watch?v=l62jlwgL3v8.
For more information about organisers: 
Erasmus MC is a single organization with a single identity. All Erasmus MC units are presented with a common name, logo, and house style. The entire range of clinical services can be found here. We distinguish two sub-brands within Erasmus MC's single identity: Erasmus MC-Sophia Children's Hospital and Erasmus MC Cancer Institute. Both of these organizational units represent specialized fields with their own reputation in national and international university medical center healthcare. For more information: https://www.erasmusmc.nl/
A weekly, international journal, publishing papers from any area of science with great potential impact and whose importance extends well beyond the confines of the specific discipline concerned. Naturealso publishes Reviews, as well as Editorials and other Opinion pieces, News and Features, News and Views, Books and Arts, and the science-fiction series, Futures. In addition, it features NatureJobs, a section on careers and recruitment, thematic supplements called Outlooks, and Technology Features. Nature publishes much online-only information, including the daily award-winning Nature News, and regular web-only collections of topical material. For more information: http://www.nature.com/nature
Nature Medicine is a biomedical research journal devoted to publishing the latest and most exciting advances in biomedical research for scientists and physicians. It publishes in fields such as infectious disease, cancer biology, cardiovascular research, gene therapy, immunology, vaccine development and neuroscience. We are proud to present unique events (some in concert with specific institutions) that will become essential resources for the researchers of today and tomorrow. For more information: http://www.nature.com/nm

Nature Reviews Molecular Cell Biology aims to be the premier source of reviews and commentaries for the scientific communities we serve. We strive to publish articles that are authoritative, accessible and enhanced with clearly understandable figures, tables and other display items. We want to provide an unparalleled service to authors, referees and readers, and we work hard to maximize the usefulness and impact of each article. The journal publishes Reviews, Perspectives, Comments and Research Highlights relevant to molecular and cell biologists, with our broad scope ensuring that the articles we publish reach the widest possible audience. For more information: https://www.nature.com/nrm
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Thursday, June 6, 2019

Insilico Medicine unveils top 3 winners of MolHack 2019

The total number of 65 participants demonstrated their phenomenal solutions in front of an esteemed panel of judges, with only 3 top winners selected

Taipei News, June 6, 2019 -- Insilico Medicine, one of the world's leading artificial intelligence (AI) companies in the field of deep learning for drug discovery, hosted an online AI competition, MolHack 2019, in Taiwan from February 25th to March 31st. With a focus on "Deep Learning for Small Molecule Generation", the event attracted top teams in deep learning and biochemistry from around the world. Insilico is now thrilled to announce the winner of the intellectual contest: Dr. Vincent Lunot, has got the first prize landing on top of a talent list to be recruited as a possible member of Insilico Taiwan's R&D team and taking back home a 15" MacBook Pro.
Traditional drug discovery efforts take years to develop new pharmaceuticals. Insilico Medicine aims to drastically shorten this time period by applying deep learning techniques. The most important aspect of deep learning AI drug discovery methods is the ability to design novel molecular structures with specific characteristics of interest. As a practical example, one may be interested in generating molecules with fingerprints (e.g. Molecular ACCess System, MACCS, fingerprint) which are similar to the desired fingerprint since some of the characteristics of a molecule may be encoded in its fingerprint. 
The total number of 65 participants registered for MolHack 2019 competition and tried their best to succeed in the main contest: to design and train Deep Neural Networks (DNNs), conditioned on molecular fingerprints, in order to generate similar new molecules based on the target MACCS fingerprints. In addition to the first prize won by Dr. Vincent Lunot, Yu Teng Tung, the second place winner, and Tsai-Min Chen and Chih-Han Huang, the third place winners, were awarded nVIDIA GeForce RTX 2080 Ti and RTX 2080 GPUs. Moreover, the three other contestants, Yu-Hsiang Huang, Chung Chen Chang, and Arash Keshavarzi Arshadi, were given special prizes for the excellent innovative solutions they came up with. 
According to Artur Kadurin, Chief Executive Officer of Insilico Taiwan Ltd., "Deep learning can accelerate the R&D of the medicines against aging and diseases, such as cancer or Alzheimer's. Traditional drug discovery is the long, arduous process of narrowing down millions of chemical compounds into mature drugs, so, the mission of the company is to shorten the time by adopting deep learning techniques."
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For further information, images or interviews, please contact::
Artur Kadurin, CEO of Insilico Taiwan Ltd. 
Email: artur@insilico.com
About Insilico Medicine
The expression in silico is an allusion to the commonly used Latin phrases in biology, in vivo, in vitro and in situ, that refer to experiments done inside living organisms, in the lab, or where they are found in nature, respectively. In silico refers to biological experiments that are "performed on silicon, via computer simulation."
Insilico Medicine is located in the Emerging Technology Center of the East Campus of Johns Hopkins University in Rockville, MD USA. It has R&D resource centers in Belgium, Russia, Taiwan, Korea, and the United Kingdom. 
Insilico Medicine pioneered applications of generative adversarial networks (GANs) and reinforcement learning for the generation of novel molecular structures for diseases with both a known target and with no known targets. It is a pioneer in the use of deep learning to assist the generation of novel molecular structures with desired characteristics. Insilico Medicine is committed to using deep learning techniques to help shorten drug development cycle time and cost and to accelerate the research and development of anti-aging and disease-related drugs.
The company collaborates with pharmaceutical companies worldwide and is pursuing new drug discovery programs in cancer, dermatological diseases, fibrosis, Parkinson's Disease, Alzheimer's Disease, ALS, diabetes, sarcopenia, and aging. 
The company's Smart's Pharma.AI division is currently a collaborative research and development partner for biotechnology, pharmaceutical, and skin care manufacturers worldwide, and provides advanced artificial intelligence learning services to many governments and foundations.
In 2017, Nvidia named Insilico Medicine as one of the Top 5 AI companies for social impact potential. In 2018, CB Insights listed the company among its global top 100 AI companies. In 2018 it received the Frost & Sullivan 2018 North American Artificial Intelligence for Aging Research and Drug Development Award accompanied by an industry brief. 


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Wednesday, June 5, 2019

Insilico Medicine to present its latest research at ICML 2019

Insilico Medicine scientists to present their latest achievements in applications of machine learning to drug discovery at the ICML EXPO
Tuesday, June 4, 2019  Insilico Medicine, a biotech company developing the end-to-end drug discovery pipeline utilizing the next generation artificial intelligence, will present its latest research at the 36th International Conference on Machine Learning in Long Beach, CA, on June 9th. Insilico Medicine is also very proud to be one of the sponsors of the event this year, which will give a unique opportunity to present our brand and to communicate with the most skilled people of artificial intelligence research. 
The International Conference on Machine Learning (ICML) is the premier gathering of professionals dedicated to the advancement of the branch of artificial intelligence known as machine learning. ICML is one of the fastest growing artificial intelligence conferences in the world. Between June 9 and June 15, 2019, at the Long Beach Convention & Entertainment Center in Long Beach, California, ICML will host over 8,000 participants. Participants at ICML span a wide range of backgrounds, from academic and industrial researchers, to entrepreneurs and engineers, to graduate students and postdocs.
This year the event kicks off with the ICML Expo held at the Long Beach Convention Center on June 9th. The main focus of the Expo workshop is the application of deep learning techniques to solving problems in drug discovery. In particular, Insilico Medicine scientists will present the applications of modern generative models giving an overview of current architectures and techniques, alongside with the company's drug discovery pipeline which utilizes multiple data types, in order to identify the most promising targets and generate novel molecular structures with the desired set of parameters. 
"We are proud to be the sponsors of ICML 2019 and have our scientists on the ground to learn and exchange ideas. In my opinion, aging research and drug discovery are the two most impactful and altruistic directions every AI scientist should consider contributing to. If you are in Los Angeles on June 9th, please register for the ICML Conference, visit our sessions and consider joining the effort," said Alex Zhavoronkov, Ph.D, Founder and CEO of Insilico Medicine. 
"With the cutting-edge neural network architectures, we can solve previously incurable diseases. With new algorithms, we can generate molecular structures satisfying challenging properties of promising drugs such as high activity, ease of synthesis and low toxicity," - said Daniil Polykovskiy, Senior Research Scientist at Insilico Medicine.
"Every year ICML gathers researchers from industry and academia bridging the gap between domains and driving the field forward. We at Insilico Medicine are applying cutting-edge research in machine learning to drug discovery and biomarker development. This event is an excellent opportunity to share experience and discuss recent progress, and we are excited to present our scientific advancements," - said Alex Zhebrak, CTO of Insilico Medicine.
You can find Insilico Medicine team during the ICML 2019 week (June 9-12) at the Insilico Medicine Booth #224.
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Expo details: Sunday, June 9th: 
Talk "Generative Models for Drug discovery" 
Hall B, at 10:30 am 
Workshop "Machine Learning for Drug discovery" 
Room 103, at 2 pm. 
For further information, images or interviews, please contact:
Contact: Klug Gehilfe 
ai@pharma.ai
Conference Website: https://icml.cc/Conferences/2019
Insilico Medicine is regularly publishing research papers in peer-reviewed journals. The company was first to apply the generative adversarial networks (GANs) to the generation of the new molecular structures with the specified parameters and published a seminal peer-reviewed paper submitted in June 2016. The concept was further extended and augmented with advanced memory and reinforcement learning. One of the latest papers published in the Journals of Gerontology demonstrated the application of the deep neural networks to assessing the biological age of the patients. The latest special issue in Molecular Pharmaceutics featured several research papers by Insilico Medicine. Insilico published an overview of its results in aging researchincluding the development of AI aging biomarkers, target identification, cross-species comparison and geroprotector discovery in Aging Research Reviews, one of the highest-impact journals in the field.
About Insilico Medicine, Inc
Insilico Medicine is an artificial intelligence company headquartered in Rockville, with R&D and management resources in Belgium, Russia, UK, Taiwan, and Korea sourced through hackathons and competitions. The company and its scientists are dedicated to extending human productive longevity and transforming every step of the drug discovery and drug development process through excellence in biomarker discovery, drug development, digital medicine, and aging research.
Insilico pioneered the applications of the generative adversarial networks (GANs) and reinforcement learning for generation of novel molecular structures for the diseases with a known target and with no known targets. In addition to working collaborations with the large pharmaceutical companies, the company is pursuing internal drug discovery programs in cancer, dermatological diseases, fibrosis, Parkinson's Disease, Alzheimer's Disease, ALS, diabetes, sarcopenia, and aging. Through a partnership with LifeExtension.com, the company launched a range of nutraceutical products compounded using the advanced bioinformatics techniques and deep learning approaches. It also provides a range of consumer-facing applications including Young.AI.
In 2017, NVIDIA selected Insilico Medicine as one of the Top 5 AI companies in its potential for social impact. In 2018, the company was named one of the global top 100 AI companies by CB Insights. In 2018 it received the Frost & Sullivan 2018 North American Artificial Intelligence for Aging Research and Drug Development Award accompanied with the industry brief. Brief company video: https://www.youtube.com/watch?v=l62jlwgL3v8.

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