GenFleet Therapeutics and Insilico Medicine Announce Strategic Partnership

SHANGHAI, July 20, 2021 /PRNewswire/ -- GenFleet Therapeutics, a clinical-stage biotechnology company focusing on cutting-edge therapies in oncology and immunology, and Insilico Medicine, an industry leader in end-to-end artificial intelligence for target discovery, small molecule chemistry, and clinical development, announced to reach strategic partnership in advancing development of novel therapies today.

The agreement outlines a constructive framework where GenFleet will synergize its own R&D systems with Insilico's end-to-end AI-powered drug discovery platform, with a view to jointly addressing significant unmet medical needs and tackling novel & difficult targets in cancer therapeutics. 

In collaboration with Insilico's AI-powered identification methods, GenFleet will enhance the exploration of the dynamic structure-activity relationship between target proteins and drug molecules through virtual structure research to develop highly selective inhibitors and deliver targeted therapies overcoming drug resistance.

Featuring a competitive pipeline with novel mechanisms, GenFleet has established its comprehensive R&D functions spanning from early discovery to global multi-regional clinical trials. In pursuing targets & indications without proof of concept global-wise, GenFleet has applied latest computational sciences to drug development including DNA-encoded Library screening, computer-aided drug design, digital clinical trial solutions, etc.

Insilico Medicine is a global leader AI-powered drug discovery company. Since 2014, Insilico Medicine developed the AI-powered drug discovery platform consisting of PandaOmics™ AI-powered novel target discovery engine, Chemistry42™ deep generative reinforcement learning system allowing for de-novo design of novel molecules with the desired properties that do not exist in the known chemical space, and InClinico™, which predicts clinical trial outcome. As a pioneer and leader in the industry, Insilico Medicine has built a strong drug discovery and development team, a broad distributed discovery partner network, and initiated multiple internal therapeutic programs.

"GenFleet's portfolio strategy is heavily based on solid technical capabilities, and since its inception, GenFleet has been leveraging such top-notch capabilities world-wide. Through the integration of conventional biotech approaches with emerging technologies such as AI and computational biology, we expect that our R&D capability and efficacy will get a tremendous boost through optimization of target screening, molecular design, real world clinical research, among others. We are very excited to form a collaboration with such leading companies as Insilico, and we look forward to some 'game-changers' out of it," said Qiang Lu, Ph.D., Co-founder and Chairman of Board of GenFleet Therapeutics.

"Through cooperation, GenFleet will reinforce its R&D systems with the AI-powered platform and we are projected to substantially improve the success rate of designing original preclinical candidate compounds in shortened cycle time. GenFleet will continuously employ new tools and techniques to enrich its cutting-edge pipeline and develop life-saving medicines for patients around the globe," said Jiong Lan, Ph.D., Co-founder and Chief Executive Officer of GenFleet Therapeutics.

"At Insilico we only partner with the companies that have the commitment to innovate using the latest advances in next-generation AI. We are very excited to collaborate with GenFleet, one of the most innovative biotechnology companies in China now working on unleashing the power of world-class artificial intelligence systems to discover and develop cutting-edge therapeutics for the benefits of the patients worldwide," said Alex Zhavoronkov, PhD, founder and CEO, Insilico Medicine.

"Embracing cooperation and innovation, Insilico is honored to form partnership with GenFleet who shares with us the commitment to innovative drug development. By analyzing and screening huge volumes of data, Insilico's AI-powered platform boasts unique generation model management and reinforcement learning techniques. We believe our collaboration will provide GenFleet with powerful assistance in its development of transformative therapies," said Feng Ren, Ph.D., Chief Scientific Officer of Insilico Medicine.

About GenFleet Therapeutics
Dedicated to serving significant unmet medical needs, GenFleet Therapeutics constructs its R&D platform on the basis of disease biology and translational medicine, and researches into latest biological mechanism of cancer pathways, tumor microenvironment and human immunoregulation. GenFleet's rich and diversified pipeline highlights multiple cutting-edge products with novel mechanisms and global intellectual property rights.

Through years of endeavor, GenFleet has set up industry-leading capabilities and expertise in developing novel drugs - both small molecules and biologics. Its cutting-edge pipeline includes over 10 products, three of which have progressed into clinical stages. As more projects move into late-stage clinical trials, GenFleet is expected to unravel its blueprint of commercialization during the next 3-5 years.

About Insilico Medicine
Insilico Medicine, an end-to-end artificial intelligence-driven drug discovery company，developing artificial intelligence platforms (www.insilico.com/platform/) that utilize deep generative models, reinforcement learning, transformer, and other modern machine learning techniques for novel target discovery and generation of novel molecular structures with desired properties. It is developing breakthrough solutions for the discovery and development of innovative drugs for cancer, fibrosis, infectious diseases, autoimmune diseases, and aging-related diseases. Since 2014, Insilico Medicine established strategic collaborations with over 30 pharmaceutical and biotechnology companies and academic research groups in the United States, Europe, China, Japan and other countries and regions, and launched multiple internal R&D pipelines for novel, difficult and previously undruggable targets. It also established a collaboration with Syngenta to develop and apply AI to sustainable agriculture. Since its inception, the company raised over $300 million from the reputable financial, biotechnology, and information technology investors.

CONTACT: pr@insilico.ai

Related Links

http://www.insilicomedicine.com

SOURCE Insilico Medicine

Deep Longevity releases psychological aging clocks and announces Scientific Advisory Board

Deep Longevity, a fully-owned subsidiary of Endurance RP Limited (SEHK stock code: 0575), released the new MindAge psychological aging clock and announced the formation of a Scientific Advisory Board (SAB) comprised of experts in longevity biotechnology

Deep Longevity, the company developing a broad range of biomarkers of aging to maintain physical health and wellness, restore youthfulness, and improve mental health and well-being, today announced the launch of its MindAge psychological aging clocks and the formation of a Science Advisory Board (SAB).

The MindAge tests are now available via the Deep Longevity website and via the Young.AI iPhone app available in the Apple Appstore. It builds on the recently published paper titled "PsychoAge and SubjAge: Development of Deep Biomarkers of Psychological and Subjective Age Using Artificial Intelligence".

The new survey-based MindAge test is available at https://www.young.ai/mind-age.

The science advisory board includes some of the most outstanding and credible researchers and medical doctors in the field working in the nascent field of longevity biotechnology and longevity medicine.

The advisory board is comprised of:

Eric Verdin, MD, CEO of the Buck Institute for Research on Aging
Daniel Kraft, MD, Stanford & Harvard trained physician-scientist. Founder of Exponential Medicine. Chair, XPrize Pandemic Alliance Task force
Morten Scheibye-Knudsen, MD, PhD, head of the biology of aging laboratory and professor at the University of Copenhagen
Vadim Gladyshev, PhD, professor, Head of the Gladyshev Laboratory at Harvard University
Wei-Wu He, PhD, Chairman of Human Longevity, Inc

The SAB will be chaired by the Chief Longevity Officer (CLO) of Deep Longevity, Alex Zhavoronkov, PhD, also the founder and CEO of Insilico Medicine and adjunct professor at the Buck Institute for Research on Aging.

The science advisory board will help direct and review the company's work in the development and applications of deep biomarkers of human aging.

The chairman of the board of directors of Endurance RP, and the founder of the London Longevity Week and The Longevity Forum, Jim Mellon, commented:

"The scientific advisors of Deep Longevity are some of the highest-impact scientists, medical doctors, and most well-known experts in longevity. Under their leadership and supervision, the company will continue developing and commercializing the biological and psychological aging clocks and engaging in research with the academic and medical institutions as well as with the insurance companies worldwide".

"Productive longevity is the most important asset we have in this life and Deep Longevity is dedicated to the measurement of aging at every level from biological to psychological. I am very happy to see the company expanding into the psychology of aging as it impacts our physical and mental health and well-being and is one of the areas we can control and intervene in", said Alex Zhavoronkov, founder and Chief Longevity Officer, of Deep Longevity and founder and CEO of Insilico Medicine.

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Paper Reference:

https://www.aging-us.com/article/202344/text

Website:

https://www.young.ai/mind-age

About Deep Longevity

Deep Longevity has been acquired by Endurance Longevity (SEHK:0575.HK), a publicly-traded company. Deep Longevity is developing explainable artificial intelligence systems to track the rate of aging at the molecular, cellular, tissue, organ, system, physiological, and psychological levels. It is also developing systems for the emerging field of longevity medicine enabling physicians to make better decisions on the interventions that may slow down, or reverse the aging processes. Deep Longevity developed Longevity as a Service (LaaS)© solution to integrate multiple deep biomarkers of aging dubbed "deep aging clocks" to provide a universal multifactorial measure of human biological age. Originally incubated by Insilico Medicine, Deep Longevity started its independent journey in 2020 after securing a round of funding from the most credible venture capitalists specializing in biotechnology, longevity, and artificial intelligence. ETP Ventures, Human Longevity and Performance Impact Venture Fund, BOLD Capital Partners, Longevity Vision Fund, LongeVC, co-founder of Oculus, Michael Antonov, and other expert AI and biotechnology investors supported the company. Deep Longevity established a research partnership with one of the most prominent longevity organizations, Human Longevity, Inc. to provide a range of aging clocks to the network of advanced physicians and researchers. https://longevity.ai/

About Endurance RP (SEHK:0575.HK)

Endurance RP is a diversified investment group based in Hong Kong currently holding various corporate and strategic investments focusing on the healthcare, wellness and life sciences sectors. The Group has a strong track record of investments and has returned approximately US$298 million to shareholders in the 21 years of financial reporting since its initial public offering.

The group recently announced the change of name to Endurance RP Limited and re-branding into Endurance Longevity to focus on fertility and longevity markets in China.

James Peyer to present at the 8th Aging Research & Drug Discovery Meeting 2021

 

 James Peyer to present new research in the biology of aging at the world's largest aging research for drug discovery conference

Thursday, July 15, 2021 -- James Peyer, Ph.D., will present the latest research on the topic "A Diversified Approach to Unlocking Geroprotector Development" at the worlds' largest annual Aging Research and Drug Discovery conference (8th ARDD). James Peyer, Ph.D., is the Chief Executive Officer and Co-Founder of Cambrian Biopharma.

"Cambrian is a Distributed Development Company (or a DisCo) advancing more than a dozen different therapeutic programs, each targeting a different driver of age-related damage. By taking this diversified approach and building a centralized team that can operate many different programs with different modalities, Cambrian can unlock the two key roadblocks that prevent us from making geroprotectors today: finding approved drugs that can reduce multi-disease risk and creating a clinical pathway to approve those drugs for prevention quickly," said James Peyer, Ph.D., Chief Executive Officer and Co-Founder of Cambrian Biopharma.

James Peyer also serves as the Chairman of the Board of Sensei Biotherapeutics and holds additional board and executive roles across Cambrian's pipeline. He has spent his entire life dedicated to the mission of finding ways to prevent people from getting diseases like cancer and Alzheimer's instead of waiting for them to get sick. James was previously Founder and Managing Partner at Apollo Ventures, the first global longevity-focused venture capital firm, investing across the US and Europe. Prior to Apollo, James was a biotech R&D specialist at the New York office of McKinsey & Company, serving major pharmaceutical clients. He earned his PhD in stem cell biology at University of Texas Southwestern Medical Center as a National Science Foundation Fellow, and his B.A. with special honors from the University of Chicago.

"Aging research is gaining traction in the biopharmaceutical industry. To my knowledge, 6 out of the top 30 pharmaceutical companies in the world prioritized aging research for early-stage discovery or therapeutic pipeline development and several companies employ artificial intelligence for this purpose. We organize the annual ARDD conference for eight years in a row and the level of interest in aging biomarkers and noticed exponential growth in registrations over the past two years", said Alex Zhavoronkov, Ph.D., co-founder and CEO of Insilico Medicine, and the founder of Deep Longevity.

Building on the success of the ARDD conferences, the organizers developed the "Longevity Medicine" course series with some of the courses offered free of charge at Longevity.Degree covered in the recent Lanced Healthy Longevity paper titled Longevity medicine: upskilling the physicians of tomorrow.

The conference proceedings of the ARDD are commonly published in peer-reviewed journals with the talks openly available at http://www.agingpharma.org. Please review the conference proceedings for 2019 and 2020.

"Aging is emerging as a druggable condition with multiple pharmaceuticals able to alter the pace of aging in model organisms. The ARDD brings together all levels of the field to discuss the most pressing obstacles in our attempt to find efficacious interventions and molecules to target aging. The 2021 conference is the best yet with top level speakers from around the globe. I'm extremely excited to be able to meet them in person at the University of Copenhagen in late summer.", said Morten Scheibye-Knudsen, MD, Ph.D., University of Copenhagen.

"Aging research is growing faster than ever on both academia and industry fronts. The ARDD meeting unites experts from different fields and backgrounds, sharing with us their latest groundbreaking research and developments. Our last ARDD meeting took place online and was a great success. This year's event will be a hybrid meeting with virtual and in-person attendees. I am particularly excited that being part of the ARDD 2021 meeting will provide an amazing opportunity for young scientists presenting their own work as well as meeting the experts in the field." said Daniela Bakula, Ph.D., University of Copenhagen

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About Aging Research for Drug Discovery Conference

At ARDD, leaders in the aging, longevity, and drug discovery field will describe the latest progress in the molecular, cellular and organismal basis of aging and the search for interventions. Furthermore, the meeting will include opinion leaders in AI to discuss the latest advances of this technology in the biopharmaceutical sector and how this can be applied to interventions. Notably, this year we are expanding with a workshop specifically for physicians where the leading-edge knowledge of clinical interventions for healthy longevity will be described. ARRD intends to bridge clinical, academic and commercial research and foster collaborations that will result in practical solutions to one of humanity's most challenging problems: aging. Our quest? To extend the healthy lifespan of everyone on the planet.

About Scheibye-Knudsen Lab

In the Scheibye-Knudsen lab we use in silico, in vitro and in vivo models to understand the cellular and organismal consequences of DNA damage with the aim of developing interventions. We have discovered that DNA damage leads to changes in certain metabolites and that replenishment of these molecules may alter the rate of aging in model organisms. These findings suggest that normal aging and age-associated diseases may be malleable to similar interventions. The hope is to develop interventions that will allow everyone to live healthier, happier and more productive lives.

About Deep Longevity

Deep Longevity has been acquired by Regent Pacific (SEHK:0575.HK), whose shares are listed on the Hong Kong Stock Exchange. Deep Longevity is developing explainable artificial intelligence systems to track the rate of aging at the molecular, cellular, tissue, organ, system, physiological, and psychological levels. It is also developing systems for the emerging field of longevity medicine enabling physicians to make better decisions on the interventions that may slow down, or reverse the aging processes. Deep Longevity developed Longevity as a Service (LaaS)© solution to integrate multiple deep biomarkers of aging dubbed "deep aging clocks" to provide a universal multifactorial measure of human biological age. Originally incubated by Insilico Medicine, Deep Longevity started its independent journey in 2020 after securing a round of funding from the most credible venture capitalists specializing in biotechnology, longevity, and artificial intelligence. ETP Ventures, Human Longevity and Performance Impact Venture Fund, BOLD Capital Partners, Longevity Vision Fund, LongeVC, co-founder of Oculus, Michael Antonov, and other expert AI and biotechnology investors supported the company. Deep Longevity established a research partnership with one of the most prominent longevity organizations, Human Longevity, Inc. to provide a range of aging clocks to the network of advanced physicians and researchers. https://deeplongevity.com/

About Endurance RP (SEHK:0575.HK)

Endurance RP is a diversified investment group based in Hong Kong currently holding various corporate and strategic investments focusing on the healthcare, wellness and life sciences sectors. The Group has a strong track record of investments and has returned approximately US$298 million to shareholders in the 21 years of financial reporting since its initial public offering. https://www.endurancerp.com/